Neurogenic orthostatic hypotension: chasing “the fall” [PDF]
Abstract Orthostatic hypotension (OH) is a frequently encountered problem affecting nearly 30% of the population aged more than 60 years. It can result from neurological and non-neurological derangements which compromise the perfusion of the brain in an erect posture. Neurogenic OH is a manifestation of autonomic failure.
Debasish Gupta, M. D. Nair
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Norepinephrine Precursor Therapy in Neurogenic Orthostatic Hypotension [PDF]
Background— In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
Horacio Kaufmann+7 more
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Psychometric validation of a patient-reported single-item assessment of ‘Good Day Bad Day’ in a neurogenic orthostatic hypotension population treated with droxidopa [PDF]
Background Symptoms of neurogenic orthostatic hypotension (nOH), including lightheadedness/dizziness, presyncope, syncope, and falls, can lead to impaired functional ability and reduced quality of life.
Clément François+5 more
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Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension [PDF]
Background Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3 randomized double-blind studies.
Italo Biaggioni+3 more
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Norepinephrine reuptake blockade to treat neurogenic orthostatic hypotension [PDF]
<jats:title>Abstract</jats:title><jats:p>GNSS satellite and receiving antennas exhibit group delay variations (GDV), which affect code pseudorange measurements. Like antenna phase center variations, which affect phase measurements, they are frequency-dependent and vary with the direction of the transmitted and received signal.
Graeme Eisenhofer, David S. Goldstein
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2198 Cognitive and behavioral side effects in patients treated with droxidopa for neurogenic orthostatic hypotension [PDF]
OBJECTIVES/SPECIFIC AIMS: To describe adverse behavioral symptoms attributed to droxidopa therapy for neurogenic orthostatic hypotension (nOH). METHODS/STUDY POPULATION: BACKGROUND: Droxidopa, a norepinephrine (NE) precursor, improves symptoms of nOH by ...
Katherine McDonell+4 more
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Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers [PDF]
Background Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic ...
Daniel O. Claassen+3 more
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Management of neurogenic orthostatic hypotension: an update [PDF]
Orthostatic hypotension (OH) is common in elderly people and in patients with disorders such as diabetes and Parkinson's disease. Grading of the severity of OH and its effect on the patient's quality of life are important. The symptoms vary with orthostatic stress, and subtle symptoms such as tiredness and cognitive impairment should be recognised ...
Phillip A. Low, Wolfgang Singer
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A validated test for neurogenic orthostatic hypotension at the bedside [PDF]
Lucy Norcliffe‐Kaufmann+2 more
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Orthostatic hypotension: An overlooked but clinically decisive entity
Orthostatic hypotension (OH) is defined as a drop of >20 mm Hg of systolic or >10 mm Hg of diastolic blood pressure (BP) within 3 min of standing from lying position. It is a common geriatric syndrome caused by impaired orthostatic response of BP.
Gunja Jain+3 more
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