Results 31 to 40 of about 56,255 (180)

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Comparing Long-term Mortality After Carotid Endarterectomy vs Carotid Stenting Using a Novel Instrumental Variable Method for Risk Adjustment in Observational Time-to-Event Data

JAMA Network Open, 2018
Key Points Question Can a novel instrumental variable method designed for time-dependent outcomes more accurately determine the relative long-term mortality after carotid endarterectomy vs carotid artery stenting?
J. Columbo, P. Martínez-Camblor, Todd A. MacKenzie, Douglas O. Staiger, R. Kang, P. Goodney, A. O’Malley   +6 more
semanticscholar   +1 more source

Transcoronary study of biomarkers in patients with heart failure: Insights into intracardiac production

ESC Heart Failure, EarlyView.
Abstract Aims Biomarkers are pivotal in the management of heart failure (HF); however, their lack of cardiac specificity could limit clinical utility. This study aimed to investigate the transcoronary changes and intracardiac production of these biomarkers.
Jie Ren, Junhan Zhao, Shengwen Yang, Shuoyan An, Chi Cai, Jing Wang, Min Gu, Hongxia Niu, Shurong Li, Wei Hua, Beiyao Gao   +10 more
wiley   +1 more source

The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients.

Stroke, 1999
BACKGROUND AND PURPOSE This study reports the surgical results in those patients who underwent carotid endarterectomy in the North American Symptomatic Carotid Endarterectomy Trial (NASCET).
G. Ferguson, M. Eliasziw, H. Barr, G. Clagett, R. Barnes, M. Wallace, D. W. Taylor, R. Haynes, J. Finan, V. Hachinski, H. Barnett   +10 more
semanticscholar   +1 more source

Percutaneous mechanical circulatory support for acute right heart failure: A practical approach

ESC Heart Failure, EarlyView.
This is an overview of percutaneous mechanical circulatory support options for acute right heart failure, illustrating key clinical scenarios, device types, and principles of tailored device selection based on haemodynamics and underlying pathology. Abstract Acute right heart failure (RHF) represents a critical entity with significant morbidity and ...
Mario Gramegna, Christophe Vandenbriele, Guido Tavazzi, Mir B. Basir, Caroline Bleakley, Mario Iannaccone, Daniel Kretzschmar, Francesco Maisano, Anna Mara Scandroglio, Benedikt Schrage, P. Christian Schultze, Gregory Serrao, Matthew Tomey, Richard Trimlett, Dirk Westermann, Matteo Montorfano, George Dangas, Susanna Price, Alaide Chieffo   +18 more
wiley   +1 more source

Pathophysiology and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting

Experimental & Translational Stroke Medicine, 2016
Cerebral hyperperfusion is a relatively rare syndrome with significant and potentially preventable clinical consequences. The pathophysiology of cerebral hyperperfusion syndrome (CHS) may involve dysregulation of the cerebral vascular system and ...
M. Farooq, C. Goshgarian, Jiangyong Min, P. Gorelick   +3 more
semanticscholar   +1 more source

Surgical Approaches to Pre‐Auricular Cutaneous Squamous Cell Carcinomas Extending to the Temporal Bone

Head &Neck, EarlyView.
ABSTRACT Background Standardized surgical approaches to advanced pre‐auricular cutaneous squamous cell carcinomas (cSCC) are lacking. Methods Fifty–four patients who underwent lateral temporal bone resection (LTBR) for pre‐auricular cSCC were grouped into “Levels” of increasing disease spread.
Michael Schachtel, Mitesh Gandhi, James Bowman, Mark Midwinter, Benedict Panizza   +4 more
wiley   +1 more source

Safety of Simultaneous Coronary Artery Bypass Grafting and Carotid Endarterectomy Versus Isolated Coronary Artery Bypass Grafting

Stroke, 2017
Background and Purpose— The optimal operative strategy in patients with severe carotid artery disease undergoing coronary artery bypass grafting (CABG) is unknown.
C. Weimar, K. Bilbilis, J. Rekowski, T. Holst, F. Beyersdorf, M. Breuer, M. Dahm, A. Diegeler, A. Kowalski, S. Martens, F. Mohr, J. Ondrášek, B. Reiter, P. Roth, R. Seipelt, M. Siggelkow, Prof. Dr. med. Gustav Steinhoff, A. Moritz, M. Wilhelmi, G. Wimmer‐Greinecker, H. Diener, H. Jakob, C. Ose, A. Scherag, S. Knipp   +24 more
semanticscholar   +1 more source

Intraoperative Completion Studies, Local Anesthesia, and Antiplatelet Medication Are Associated With Lower Risk in Carotid Endarterectomy

Stroke, 2017
Background and Purpose— In Germany, all surgical and endovascular procedures on the carotid bifurcation must be documented in a statutory nationwide quality assurance database.
C. Knappich, A. Kuehnl, P. Tsantilas, Sofie Schmid, Thorben Breitkreuz, M. Kallmayer, A. Zimmermann, H. Eckstein   +7 more
semanticscholar   +1 more source

Quantitative susceptibility mapping of the human carotid artery: Assessing sensitivity to elastin and collagen ex vivo

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose The aim is to establish the relationship between carotid susceptibility and microstructural components in diseased carotid arteries. Methods Excised cadaveric carotid arteries (n = 5) were scanned using high‐resolution QSM at 7 Tesla. After ex vivo imaging, all samples were brought to histology and stained for elastin, collagen, cells,
Alan J. Stone, Brooke Tornifoglio, Francesco Digeronimo, Karin Shmueli, Caitríona Lally   +4 more
wiley   +1 more source