Results 31 to 40 of about 32,411 (169)
Advanced Science, EarlyView.Patients with osteoporosis face a higher risk of bone injury, mainly due to weakened osteogenic differentiation and bone formation, along with increased osteoclast differentiation and bone resorption activity, leading to bone homeostasis imbalance.
Xinhui Wu +13 more
wiley +1 more source
High‐Density Flexible Neural Implants with Submicron Feedline Resolution
Advanced Electronic Materials, EarlyView.Optimization of microfabrication methods using optical contact lithography (OCL) and electron beam lithography (EBL) enables the fabrication of 64‐channel, high‐density, parylene‐C‐based intracortical implants with submicron feedlines as narrow as 400 and 50 nm, respectively.
Lina Koschinski +10 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.The association between BMD reduction during NAC and the worse prognosis remains unknown, although NAC followed by esophagectomy is a standard treatment for advanced ESCC. This study appeared that BMD massive reduction was an independent prognostic factor on OS (HR, 3.30; 95% confidence interval [CI], 1.69–6.55) and RFS (HR, 2.08; 95% CI, 1.19–3.63 ...
Kazuhide Sato +11 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu +7 more
wiley +1 more source
Animal Research and One Health, EarlyView.The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li +5 more
wiley +1 more source
SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem, EarlyView.The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic +15 more
wiley +1 more source
Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function
Chemistry – A European Journal, EarlyView.Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler +28 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.This study is related to the development of a microextraction method for the determination of 56 psychoactive substances in oral fluid. Sample clean‐up is obtained by parallel artificial liquid membrane extraction and analyzed by liquid chromatography–tandem mass spectrometry.
Martina Croce +6 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation and increases patient morbidity and mortality. Due to the complex and limited understanding of RVF pathophysiology, efforts to prognosticate RVF after LVAD have been challenging.
Abdul‐Fatawu Osman +11 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Investigate real‐world outcomes in drug‐resistant epilepsy (DRE) patients treated with cenobamate as adjunctive treatment to other antiseizure medications (ASMs) within the Early Access Programs (EAP) in Germany, France, and the United Kingdom.
Sylvain Rheims +13 more
wiley +1 more source