Results 31 to 40 of about 391,284 (388)
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Journal of Clinical Oncology, 2020 PURPOSE
To provide recommendations on genetic and tumor testing for women diagnosed with epithelial ovarian cancer based on available evidence and expert consensus.P. Konstantinopoulos, B. Norquist, C. Lacchetti, D. Armstrong, R. Grisham, P. Goodfellow, E. Kohn, D. Levine, Joyce F. Liu, K. Lu, Dee Sparacio, C. Annunziata +11 moresemanticscholar +1 more sourceTherapeutic Implications of Germline Testing in Patients With Advanced Cancers
Journal of Clinical Oncology, 2021 PURPOSE Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation profiling guides therapy selection in patients with advanced cancer.Z. Stadler, A. Maio, D. Chakravarty, Y. Kemel, M. Sheehan, E. Salo-Mullen, K. Tkachuk, Christopher J. Fong, Bastien Nguyen, Amanda Erakky, K. Cadoo, Ying L. Liu, M. Carlo, Alicia J Latham, Hongxin Zhang, Ritika Kundra, Shaleigh A. Smith, Jesse Galle, C. Aghajanian, N. Abu-Rustum, A. Varghese, E. O’Reilly, M. Morris, W. Abida, M. Walsh, A. Drilon, G. Jayakumaran, A. Zehir, M. Ladanyi, O. Ceyhan-Birsoy, D. Solit, N. Schultz, M. Berger, D. Mandelker, L. Diaz, K. Offit, M. Robson +36 moresemanticscholar +1 more sourceComprehensive germline and somatic genomic profiles of Chinese patients with biliary tract cancer
Frontiers in Oncology, 2022 BackgroundBiliary tract cancer (BTC) is an uncommon but highly lethal malignancy with poor clinical outcomes. To promote the development of precision medicine for BTC, uncovering its genomic profile becomes particularly important. However, studies on the Haipeng Yu, Haipeng Yu, Haipeng Yu, Yan Xu, Yan Xu, Yan Xu, Wei Gao, Wei Gao, Wei Gao, Mei Li, Mei Li, Mei Li, Ji’an He, Ji’an He, Ji’an He, Xiaoqian Deng, Wenge Xing, Wenge Xing, Wenge Xing +18 moredoaj +1 more sourceDefending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]
, 2013 The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...A Aravin, A Dupressoir, A Dupressoir, A Dupressoir, A Fadloun, A Inagaki, A Inoue, A Inoue, A Meissner, A Prokhortchouk, A Puech, A Sookdeo, A Tsumura, A Vourekas, AA Aravin, AA Aravin, AA Aravin, AA Zabolotneva, AE Peaston, AR Muotri, AR Muotri, B Hendrich, BH Schrans-Stassen, C Chen, C Lu, C Popp, C-X Song, C-X Song, CE Nestor, CG Lian, CM Davis, CP Walsh, D Bourc’his, D Bourc’his, D Branciforte, D Guallar, D Haig, D Lucifero, D Lucifero, D Reiss, D Ribet, D Ribet, D Ribet, D Sproul, D Wolf, D Wolf, DA Kramerov, DC Hancks, DJ Lees-Murdock, DM Maatouk, Donncha S. Dunican, DS Dunican, DT Ting, E Beyret, E Beyret, E Khazina, E Li, EB Chuong, EL Kuff, ES Lander, F Santos, F Yang, FD Araujo, G Hutvagner, G Velasco, GD Evrony, H Cedar, H Cedar, H Heyn, H Kano, H Khan, H Kobayashi, H Stroud, HJ Cooke, HM Rowe, HM Rowe, HM Rowe, I Cantone, I Martín Caballero, I Suetake, IA Maksakova, Ian R. Adams, J Borgel, J Brennecke, J Chen, J Gimenez, J Lange, J Reichmann, J Reichmann, J Rossant, J Sharif, J Xiol, J-H Ng, JA Hackett, JA Hackett, JA Yoder, James H. Crichton, JD Lewis, JK Baillie, JL Garcia-Perez, JL Goodier, JN Athanikar, JO Kriegs, JP Reddington, JP Reddington, JP Thomson, JP Thomson, JV Moran, K Dennis, K Hata, K Hayashi, K Hisada, K Kurimoto, K Myant, K Zheng, K Zheng, KP Koh, L Jackson-Grusby, L Ma, L Piko, L Shen, L-Q Sun, LK Hutnick, M Abe, M Chotalia, M Denne, M Dewannieux, M Dewannieux, M Dewannieux, M Freitag, M Kaneda, M Kaneda, M Ko, M Ko, M Leeb, M Okano, M Reuter, M Reuter, M Ruggiu, M Saitou, M Shoji, M Tachibana, M Tahiliani, M Weber, M Wiench, M Xu, MA Carmell, Marie MacLennan, MC Ward, MM Dawlaty, MM Dawlaty, MM Karimi, MT Romanish, N Bannert, N Gilbert, N Lane, N Mathioudakis, N Reynolds, N Yang, N Zamudio, OH Tam, P Hajkova, P Hajkova, PJ Skene, Q Feng, Q Yan, R Brunmeir, R Burdick, R Fuente De La, R Illingworth, R Lister, R Rebollo, R Shukla, R Yaman, R Öllinger, RH Waterston, Richard R. Meehan, RJ DeBerardinis, RJA Frost, RR Meehan, S Chuma, S Fazio De, S Guibert, S Ito, S Ito, S Kagiwada, S Kaufmann, S Kuntz, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Mi, S Milutinovic, S Salle La, S Schütt, S Seisenberger, S Solyom, S Takebayashi, S Yamaguchi, S-H Lee, SA Smallwood, SA Trelogan, SB Rothbart, SFC Soper, SK Mahadevaiah, SL Martin, SL Martin, SL Martin, SL Mathias, SP Sripathy, SS Tanaka, ST Grivna, T Matsui, T Singer, T Tanaka, T Watanabe, T Watanabe, T Watanabe, T-P Gu, TS Macfarlan, UM Galli, V Chapman, VV Vagin, W Deng, W Filipowicz, W Seifarth, W Wei, W Yan, WA Pastor, X Cai, X Nan, Y Kato, Y Seki, Y Tao, Y Unhavaithaya, Y Yabuta, Y Yotsuyanagi, Y-Q Su, Z Li, ZD Smith, ZD Smith +241 morecore +1 more sourceMaintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
New England Journal of Medicine, 2019 BACKGROUND
Patients with a germline BRCA1 or BRCA2 mutation make up a small subgroup of those with metastatic pancreatic cancer. The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor olaparib has had antitumor activity in this population ...T. Golan, P. Hammel, M. Reni, E. Van Cutsem, T. Macarulla, M. Hall, Joon-Oh Park, D. Hochhauser, D. Arnold, D. Oh, A. Reinacher-Schick, G. Tortora, H. Algül, E. O’Reilly, D. McGuinness, K. Cui, K. Schlienger, G. Locker, H. Kindler +18 moresemanticscholar +1 more sourceTalazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation
New England Journal of Medicine, 2018 BACKGROUND The poly(adenosine diphosphate‐ribose) inhibitor talazoparib has shown antitumor activity in patients with advanced breast cancer and germline mutations in BRCA1 and BRCA2 (BRCA1/2). METHODS We conducted a randomized, open‐label, phase 3 trial J. Litton, H. Rugo, J. Ettl, S. Hurvitz, A. Gonçalves, Kyung-Hun Lee, L. Fehrenbacher, R. Yerushalmi, L. Mina, Miguel Martín, H. Roché, Y. Im, R. Quek, D. Markova, I. C. Tudor, A. Hannah, W. Eiermann, J. Blum +17 moresemanticscholar +1 more sourceThe Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia
Frontiers in Cell and Developmental Biology, 2021 ETV6-RUNX1 is almost exclusively associated with childhood B-cell acute lymphoblastic leukemia (B-ALL), but the consequences of ETV6-RUNX1 expression on cell lineage decisions during B-cell leukemogenesis are completely unknown.Guillermo Rodríguez-Hernández, Guillermo Rodríguez-Hernández, Ana Casado-García, Ana Casado-García, Marta Isidro-Hernández, Marta Isidro-Hernández, Daniel Picard, Javier Raboso-Gallego, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Silvia Alemán-Arteaga, Alberto Orfao, Alberto Orfao, Oscar Blanco, Oscar Blanco, Susana Riesco, Susana Riesco, Pablo Prieto-Matos, Pablo Prieto-Matos, Francisco Javier García Criado, Francisco Javier García Criado, María Begoña García Cenador, María Begoña García Cenador, Hanno Hock, Tariq Enver, Isidro Sanchez-Garcia, Isidro Sanchez-Garcia, Carolina Vicente-Dueñas, Carolina Vicente-Dueñas +28 moredoaj +1 more sourceGermline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]
, 2013 Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.Anderson, Peter M, Angelo, Laura S, Benjamin, Robert S, Fu, Siqing, Herzog, Cynthia E, Janku, Filip, Jiang, Yunyun, Kurzrock, Razelle, Naing, Aung, Subbiah, Vivek +9 morecore +3 more sourcesManta: rapid detection of structural variants and indels for germline and cancer sequencing applications
Bioinform., 2016 UNLABELLED
: We describe Manta, a method to discover structural variants and indels from next generation sequencing data. Manta is optimized for rapid germline and somatic analysis, calling structural variants, medium-sized indels and large insertions on Xiaoyu Chen, Ole Schulz-Trieglaff, Richard Shaw, B. Barnes, F. Schlesinger, Morten Källberg, A. Cox, S. Kruglyak, C. T. Saunders +8 moresemanticscholar +1 more source
