Results 31 to 40 of about 825,099 (241)
Bayesian tensor factorization for predicting clinical outcomes using integrated human genetics evidence [PDF]
arXiv, 2022 The approval success rate of drug candidates is very low with the majority of failure due to safety and efficacy. Increasingly available high dimensional information on targets, drug molecules and indications provides an opportunity for ML methods to integrate multiple data modalities and better predict clinically promising drug targets.
arxiv
The genetics of human obesity [PDF]
Annals of the New York Academy of Sciences, 2013 It has long been known that there is a genetic component to obesity, and that characterizing this underlying factor would likely offer the possibility of better intervention in the future. Monogenic obesity has proved to be relatively straightforward, with a combination of linkage analysis and mouse models facilitating the identification of multiple ...
Struan F.A. Grant +2 more
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Genetics in human reproduction
JBRA Assisted Reproduction, 2020 Approximately 50% of the causes of infertility are of genetic origin. The objective of this study was to analyze the role of genetics in human reproduction by reviewing the main genetic causes of infertility and the use of preimplantation genetic testing in Brazil.
Vivian de Oliveira Rodrigues +3 more
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Zeithistorische Forschungen, 2013 To this day, there is no comprehensive account of the history of genetic counseling in the FRG. This is surprising, as studying the connections between counseling practice and disability as well as concepts and critique of Human Genetics allows for an ...
Britta-Marie Schenk
doaj +1 more source
BMC Neurology, 2022 Background Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, long-term condition characterised by post-exertional malaise, often with fatigue that is not significantly relieved by rest.
Andy Devereux-Cooke +27 more
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The evolution of genetic architectures underlying quantitative traits [PDF]
Proc. R. Soc. B 280:1769, 2012 In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across diverse taxa, producing observations that sometimes contrast with Fisher's blueprint.
arxiv +1 more source
Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases [PDF]
Journal of Caffeine and Adenosine Research, New Rochelle, N.Y. :
Mary Ann Liebert, Inc., [2018]-, 2019, 9 (3), pp.73-88, 2020 Adenosine receptors are G-protein-coupled receptors involved in a wide range of physiological and pathological phenomena in most mammalian systems. All four receptors are widely expressed in the central nervous system, where they modulate neurotransmitter release and neuronal plasticity. A large number of gene association studies have shown that common
arxiv +1 more source
The genetics of human personality [PDF]
Genes, Brain and Behavior, 2017 Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology.
S. Sanchez‐Roige +4 more
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Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Nature Communications, 2021 Arab populations are relatively understudied, especially their genetic architecture and historical relationship with early founders of the ancient Near East.
Rozaimi Mohamad Razali +10 more
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Genetics of human cataract [PDF]
Clinical Genetics, 2013 The pathogenesis of inherited cataracts of all kinds recapitulates the developmental and cell biology of the lens. Just as each novel mutation provides additional information about the structural or functional biology of the affected gene, each newly identified gene provides insight into the developmental and cellular biology of the lens.
Alan Shiels, J. F. Hejtmancik
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