Results 31 to 40 of about 16,602 (182)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Revealing the Impact of Mono(2‐ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mono(2‐ethylhexyl) phthalate (MEHP) is a ubiquitous environmental contaminant and endocrine‐disrupting chemical (EDC), identified as a potential carcinogen. Emerging studies have begun to elucidate the impact of MEHP on prostate cancer (PCa), yet its pathogenic effects and the underlying molecular mechanisms remain unclear. This study seeks to
Chenyu Liang, Weicheng Tian, Hengxi Zeng, Ziyang Xia, Zijie Luo, Yue Zhuo, Minlian Pan, Kangbu Wu, Siyu Xiong, Xuejing Lin, Xinchun Li, Jiaxi Yu   +11 more
wiley   +1 more source

Introduction of a modified single stage reconstruction technique of male penopubic epispadias

BMC Urology, 2022
Objective To represent the long-term outcomes of our modified single-stage technique for the reconstruction of isolated penopubic epispadias in male patients.
Masoud Bitaraf, Pouya Mahdavi Sharif, Parham Torabinavid, Abdol-Mohammad Kajbafzadeh   +3 more
doaj   +1 more source

Evaluating antimicrobial effectiveness in acute uncomplicated cystitis: A retrospective single‐center study

Journal of General and Family Medicine, EarlyView.
Abstract Background Acute uncomplicated cystitis (AUC) is a urinary tract infection and is generally treated using antimicrobial therapy. Escherichia coli is the main causative agent of AUC. Recently, the prevalence of fluoroquinolone (FQ)‐resistant‐E. coli has demonstrated a noticeable increase. In this study, we aimed to investigate the effectiveness
Takuhisa Nukaya, Kiyohito Ishikawa, Ryoichi Shiroki   +2 more
wiley   +1 more source

Scrotodynia successfully treated with botulinum toxin [PDF]

Surgical & Cosmetic Dermatology
Scrotodynia, or genital dysesthesia, is characterized by chronic scrotal pain lasting at least 3 months, with no identifiable etiology despite thorough investigation.
Taciana Dal'Forno, Martina Souilljee Birck   +1 more
doaj   +1 more source

The Role of LIM Kinase in the Male Urogenital System

Cells, 2021
The LIM kinases (LIMK1 and LIMK2), known as downstream effectors, and the Rho-associated protein kinase (ROCK), a regulator of actin dynamics, have effects on a diverse set of cellular functions.
Juhyun Park, Soo Woong Kim, Min Chul Cho
doaj   +1 more source

Diagnosis and management of reactive infectious mucocutaneous eruption

Journal of Hospital Medicine, EarlyView.
Abstract Medicine's clinical understanding of reactive infectious mucocutaneous eruption (RIME) has evolved over time. It was previously described as Mycoplasma pneumoniae‐induced rash and mucositis (MIRM), and before that as a variant of Stevens‐Johnson Syndrome/Toxic Epidermal Necrolysis. Here, we summarize the current understanding of best practices
Nicole Damari, Abbie Goodman, Catherine Bridges   +2 more
wiley   +1 more source

Outcomes of Organ‐Preserving Local Excision Compared to Radical Resection in Stage I Early‐Onset Rectal Cancer: A Propensity‐Score SEER‐Based Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Organ‐preserving approaches to rectal cancer have shown promising results in reducing adverse events and improving quality of life without compromising oncologic outcomes. This study aimed to compare the outcomes of organ‐preserving local excision (LE) and radical resection (RR) for patients with stage I early‐onset rectal cancer ...
Spencer Barnes, Sameh Hany Emile, Anjelli Wignakumar, Justin Dourado, Cameron Perrone, Matthew Bilotti, Steven D. Wexner   +6 more
wiley   +1 more source

Ecchymosis on the penis, scrotum and pubis

The Pan African Medical Journal, 2017
A 52-year-old male patient with a mechanical prosthetic valve, in use of the combination of aspirin and warfarin, presented to the emergency department after 12 hours of a blunt injury of erect penis during sexual intercourse.
Glauber Voltan, Fred Bernardes Filho
doaj   +1 more source

Role of Gynecologic Findings in Interstitial Cystitis/Bladder Pain Syndrome: A Consensus

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To evaluate the role of gynecologic findings in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by reviewing current international guidelines and identifying relevant gynecologic co‐morbidities. Methods This consensus statement was developed through a systematic four‐phase process: (1) comprehensive literature review across ...
Marie E. Sullivan, Amr El Haraki, Anna Padoa, Katy Vincent, Kristene E. Whitmore, Mauro Cervigni   +5 more
wiley   +1 more source