Results 31 to 40 of about 282,753 (347)

Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

Genome Biology, 2018
Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies that have mapped genome-
Heath E. O’Brien, E. Hannon, Matthew J. Hill, Carolina C. Toste, Matthew J. Robertson, Joanne E. Morgan, Gemma McLaughlin, C. Lewis, Leonard C. Schalkwyk, L. Hall, A. Pardiñas, Michael J. Owen, Michael C. O’Donovan, Jonathan Mill, Nicholas J. Bray   +14 more
semanticscholar   +1 more source

Near-periodic substitution and the genetic variance induced by environmental change [PDF]

, 2006
We investigate a model that describes the evolution of a diploid sexual population in a changing environment. Individuals have discrete generations and are subject to selection on the phenotypic value of a quantitative trait, which is controlled by a ...
Barton, Barton, Barton, Broom, Bulmer, Bulmer, Bürger, Bürger, Charlesworth, Crow, D. Waxman, Gardner, Gavrilets, Kimura, Lande, Lynch, Maynard Smith, Maynard Smith, Russell, Shpak, Turelli, Turelli, Van Valen, Waxman, Waxman, Waxman, Waxman, Welch, Wright, Y. Bello   +29 more
core   +3 more sources

A powerful global test for spliceQTL effects

Biometrical Journal, Volume 65, Issue 1, January 2023., 2023
Abstract Statistical methods to test for effects of single nucleotide polymorphisms (SNPs) on exon inclusion exist but often rely on testing of associations between multiple exon–SNP pairs, with sometimes subsequent summarization of results at the gene level. Such approaches require heavy multiple testing corrections and detect mostly events with large
Renee X. de Menezes, Armin Rauschenberger, BIOS Consortium, Peter A. C. 't Hoen, Marianne A. Jonker   +4 more
wiley   +1 more source

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci

Nucleic Acids Research, 2018
Quantitative trait locus (QTL) mapping of molecular phenotypes such as metabolites, lipids and proteins through genome-wide association studies represents a powerful means of highlighting molecular mechanisms relevant to human diseases.
D. Stacey, E. Fauman, D. Ziemek, B. Sun, E. Harshfield, A. Wood, A. Butterworth, K. Suhre, D. Paul   +8 more
semanticscholar   +1 more source

Expression quantitative trait loci analysis in plants [PDF]

, 2010
An expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population.
Chen, Xinwei, Druka, Arnis, Jiang, Ning, Kearsey, Mike, Luo, Zewei, Potokina, Elena, Waugh, Robbie   +6 more
core   +2 more sources

Prioritizing quantitative trait loci for root system architecture in tetraploid wheat

Journal of Experimental Botany, 2016
Optimization of root system architecture (RSA) traits is an important objective for modern wheat breeding. Linkage and association mapping for RSA in two recombinant inbred line populations and one association mapping panel of 183 elite durum wheat ...
M. Maccaferri, Walid M. El-Feki, G. Nazemi, S. Salvi, M. Cane’, M. C. Colalongo, S. Stefanelli, R. Tuberosa   +7 more
semanticscholar   +1 more source

Heritability and tissue specificity of expression quantitative trait loci. [PDF]

PLoS Genetics, 2006
Variation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling and linkage analysis to the regulation of gene
Enrico Petretto, Jonathan Mangion, Nicholas J Dickens, Stuart A Cook, Mande K Kumaran, Han Lu, Judith Fischer, Henrike Maatz, Vladimir Kren, Michal Pravenec, Norbert Hubner, Timothy J Aitman   +11 more
doaj   +1 more source

Interpreting Functional Impact of Genetic Variations by Network QTL for Genotype–Phenotype Association Study

Frontiers in Cell and Developmental Biology, 2022
An enormous challenge in the post-genome era is to annotate and resolve the consequences of genetic variation on diverse phenotypes. The genome-wide association study (GWAS) is a well-known method to identify potential genetic loci for complex traits ...
Kai Yuan, Tao Zeng, Tao Zeng, Tao Zeng, Luonan Chen, Luonan Chen, Luonan Chen, Luonan Chen   +7 more
doaj   +1 more source

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

Construction of a high-density genetic map by specific locus amplified fragment sequencing (SLAF-seq) and its application to Quantitative Trait Loci (QTL) analysis for boll weight in upland cotton (Gossypium hirsutum.)

BMC Plant Biology, 2016
Upland Cotton (Gossypium hirsutum) is one of the most important worldwide crops it provides natural high-quality fiber for the industrial production and everyday use.
Zhen Zhang, Haihong Shang, Yuzhen Shi, Long Huang, Jun-wen Li, Qun Ge, Juwu Gōng, Ai-ying Liu, Tingting Chen, Dan Wang, Yanling Wang, Koffi Kibalou Palanga, Jamshed Muhammad, Weijie Li, Quanwei Lu, Xiaoying Deng, Yunna Tan, Weiwu Song, Juan Cai, Peng-tao Li, H. Rashid, Wànkuí Gǒng, You-lu Yuan   +22 more
semanticscholar   +1 more source