GSK3-beta as a candidate therapeutic target in soft tissue sarcomas
Journal of Hematology & Oncology, 2021 Soft tissue sarcoma (STS) is a predominantly fatal rare malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies. Its therapeutic relevance in STS is unknown.
S. Verbeke +7 more
doaj +1 more source
Predicting Distant Metastases in Soft-Tissue Sarcomas from PET-CT scans using Constrained Hierarchical Multi-Modality Feature Learning [PDF]
, 2021 Distant metastases (DM) refer to the dissemination of tumors, usually, beyond the organ where the tumor originated. They are the leading cause of death in patients with soft-tissue sarcomas (STSs). Positron emission tomography-computed tomography (PET-CT) is regarded as the imaging modality of choice for the management of STSs.
arxiv +1 more source
Biphenotypic Sinonasal Sarcoma-Case Report and Review of Clinicopathological Features and Diagnostic Modalities. [PDF]
, 2019 Background Biphenotypic sinonasal sarcoma is a recently described malignancy showing dual differentiation with both myogenic and neural elements. Due to its histologic similarities to other sinonasal malignancies, it is a diagnostic challenge.
Chitguppi, Chandala +6 more
core +2 more sources
Translational Oncology, 2017 BACKGROUND: The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders.
Katja Maretty-Kongstad +3 more
doaj +1 more source
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]
, 2018 BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara +6 more
core +2 more sources
Cancer Medicine, 2020 Background Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type.
Masanori Okamoto +14 more
doaj +1 more source
Predictive and prognostic transcriptomic biomarkers in soft tissue sarcomas
npj Precision Oncology, 2021 Soft tissue sarcomas (STS) are rare and heterogeneous tumours comprising over 80 different histological subtypes. Treatment options remain limited in advanced STS with high rates of recurrence following resection of localised disease.
Eve Merry +3 more
doaj +1 more source
Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]
, 2013 Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.
Anderson, Peter M +9 more
core +3 more sources
Extra medullar Granulocytic sarcoma: a case report of an exceptional localization [PDF]
, 2020 Granulocytic sarcoma is a rare type of tumor composed of extramedullary immature cells. The breast location is very rare; it accounts for less than 8% of cases.
Khaled, Rahal +5 more
core +2 more sources
Soft Tissue Sarcoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
The Journal of the National Comprehensive Cancer Network, 2016 Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues.
M. von Mehren +29 more
semanticscholar +1 more source