Results 31 to 40 of about 48,005 (315)
Cancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023 Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu +3 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 94-106, January 2023., 2023 Abstract Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate metabolizers (EMs) or poor metabolizers (PMs) to determine pharmacokinetic exposure of parent drug ...
Frank Schneider +7 more
wiley +1 more source
A novel ultrasound-guided mouse model of sudden cardiac arrest.
PLoS ONE, 2020 AimMouse models of sudden cardiac arrest are limited by challenges with surgical technique and obtaining reliable venous access. To overcome this limitation, we sought to develop a simplified method in the mouse that uses ultrasound-guided injection of ...
Cody A Rutledge +5 more
doaj +1 more source
Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason +2 more
wiley +1 more source
Current behavior of sudden cardiac arrest and sudden death [PDF]
Archivos de cardiolog�a de M�xico (English ed. Internet), 2020 Sudden cardiac arrest (SCA) and sudden death (SD) continue to be a global public health problem, although the true incidence is unknown, it is estimated that they are responsible for 30% of cardiac origin mortality and may represent 20% of total mortality in adults.
José L. Salas-Pacheco +2 more
openaire +4 more sources
Türk Kardiyoloji Derneği Arşivi, 2019 Massive pulmonary embolism is a well-known cause of sudden cardiac arrest in the adult population. Systemic fibrinolysis can be a life-saving option. Therapeutic hypothermia is highly recommended for nontraumatic sudden cardiac arrest victims to minimize
Ali Çoner, Tayfun Birtay
doaj +1 more source
BMC Cardiovascular Disorders, 2011 Background Epidemiologic evidence suggests a heritable component to risk for sudden cardiac arrest independent of risk for myocardial infarction. Recent candidate gene association studies for community sudden cardiac arrests have focused on a limited ...
Olgin Jeffrey E +6 more
doaj +1 more source
Two women presenting aborted sudden cardiac arrest as the first event of mitral valve disease [PDF]
Acute and Critical Care, 2018 Mitral valve prolapse (MVP) is a relatively common valvular heart disease and is known to have a benign course. However, a certain subtype of MVP has a pathologic prognosis and can be accompanied by malignant cardiac arrhythmia causing sudden cardiac ...
Sua Kim, Jae Min Shim, Seong-Mi Park
doaj +1 more source
A novel approach for the diagnosis of ventricular tachycardia based on phase space reconstruction of ECG [PDF]
International Journal of Cardiology, Volume 172, Issue 1, March
2014, Pages e31-e33, 2014 Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease.
arxiv +1 more source
Journal of Arrhythmia, 2023 Background Determining the pathogenesis of sudden cardiac arrest (SCA) in children is crucial for its management and prognosis. Our aim is to analyze the role of broad genetic testing in the prevention, diagnosis, and prognosis of SCA in Children ...
Miry Blich +7 more
doaj +1 more source