Results 31 to 40 of about 14,174,741 (341)

Interaction of bepridil with the cardiac troponin C/troponin I complex [PDF]

FEBS Letters, 2001
We have investigated the binding of bepridil to calcium‐saturated cardiac troponin C in a cardiac troponin C/troponin I complex. Nuclear magnetic resonance spectroscopy and [15N,2H]cardiac troponin C permitted the mapping of bepridil‐induced amide proton chemical shifts. A single bepridil‐binding site in the regulatory domain was found with an affinity
Ekram Abusamhadneh, Alex Dvoretsky, Paul R. Rosevear, Natosha Finley, Soumya Sasi, M. Bret Abbott   +5 more
openaire   +3 more sources

Troponin I

Definitions, 2020
Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction.

semanticscholar   +1 more source

Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium

European Heart Journal, 2016
Aims Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE ...
S. Blankenberg, V. Salomaa, N. Makarova, F. Ojeda, P. Wild, K. Lackner, T. Jørgensen, B. Thorand, A. Peters, M. Nauck, A. Petersmann, E. Vartiainen, G. Veronesi, P. Brambilla, S. Costanzo, L. Iacoviello, G. Linden, J. Yarnell, C. Patterson, Brendan M. Everett, P. Ridker, J. Kontto, R. Schnabel, W. Koenig, F. Kee, T. Zeller, K. Kuulasmaa   +26 more
semanticscholar   +1 more source

Avaliação dos valores séricos de troponina I cardíaca em crianças menores de 1 ano de idade Evaluation of serum cardiac troponin I values in children less than 1 year of age

Brazilian Journal of Cardiovascular Surgery, 2008
OBJETIVO: Verificar os valores séricos para troponina I cardíaca em crianças abaixo de um ano de idade, sem disfunção cardíaca clínica. MÉTODOS: Os níveis séricos de troponina I cardíaca foram determinados em 99 crianças com idade abaixo de um ano ...
Antonio Carlos Arruda Souto, Werther Brunow de Carvalho   +1 more
doaj   +1 more source

Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T

FEBS Open Bio, 2015
The α‐helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy.
Shirin Akhter, J.-P. Jin
doaj   +1 more source

Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils

Frontiers in Physiology, 2011
Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little, Svetlana B Tikunova, Darl R. Swartz, Catalina eNorman, Jonathan P Davis   +4 more
doaj   +1 more source

Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

Circulation, 2018
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction with a ...
N. H. D. Linden, K. Wildi, R. Twerenbold, J. Pickering, M. Than, L. Cullen, L. Cullen, L. Cullen, J. Greenslade, J. Greenslade, W. Parsonage, W. Parsonage, W. Parsonage, T. Nestelberger, J. Boeddinghaus, P. Badertscher, M. Gimenez, Lieke J. J. Klinkenberg, O. Bekers, A. Schöni, D. Keller, Z. Sabti, C. Puelacher, Janosch Cupa, L. Schumacher, N. Kozhuharov, Karin Grimm, S. Shrestha, D. Flores, M. Freese, C. Stelzig, I. Strebel, Ò. Miró, K. Rentsch, B. Morawiec, D. Kawecki, Wanda Kloos, J. Lohrmann, A. Richards, R. Troughton, C. Pemberton, S. Osswald, M. P. Dieijen-Visser, A. Mingels, T. Reichlin, S. Meex, C. Mueller   +46 more
semanticscholar   +1 more source

Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm.

JAMA cardiology, 2016
IMPORTANCE Rapid and accurate diagnosis of acute myocardial infarction (AMI) currently constitutes an unmet need. OBJECTIVE To test a 1-hour diagnostic algorithm to diagnose AMI using a high-sensitivity troponin I assay with a new cutoff level of 6 ng ...
J. Neumann, N. Sörensen, T. Schwemer, F. Ojeda, Rafael Bourry, V. Sciacca, Sarina Schaefer, C. Waldeyer, C. Sinning, T. Renné, M. Than, W. Parsonage, K. Wildi, N. Makarova, R. Schnabel, U. Landmesser, C. Mueller, L. Cullen, J. Greenslade, T. Zeller, S. Blankenberg, M. Karakas, D. Westermann   +22 more
semanticscholar   +1 more source

Troponin T and troponin I at acut coronary sendrom

Turkish Bulletin of Hygiene and Experimental Biology, 2011
Objective: Troponins and tropomyosins are not only the structural proteins that play roles in arrangement of skeletal and heart muscles, but also sensitive and spesific markers of heart muscle damage. In this study we aimed to compare the values of sensitivity, specifity, positive and negative predictive values of troponin T and troponin I which were ...
Canan Topcuoglu, Mehmet Avcikucuk, Ali Guctekin, Fatih Bakir   +3 more
openaire   +2 more sources

Novel high-sensitivity cardiac troponin I assay in patients with suspected acute coronary syndrome

Heart, 2018
Background High-sensitivity cardiac troponin assays enable the early risk stratification of patients with suspected acute coronary syndrome to identify those at low risk of myocardial infarction or cardiac death.
A. Chapman, T. Fujisawa, K. Lee, J. Andrews, A. Anand, D. Sandeman, A. Ferry, S. Stewart, L. Marshall, F. Strachan, A. Gray, D. Newby, Anoop S. V. Shah, N. Mills   +13 more
semanticscholar   +1 more source