Results 41 to 50 of about 232,551 (308)

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj   +1 more source

Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H₂AX, CHK2 and p53

Cells, 2022
Herein, the apoptotic mechanism of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) was examined in cisplatin-resistant lung cancer cells. PGG significantly reduced viability; increased sub-G1 accumulation and the number of terminal deoxynucleotidyl ...
Ji-Hyun Kim, Eunji Im, Jihyun Lee, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Hyeon Hee Kwon, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim   +10 more
doaj   +1 more source

Effect of Chronic Caffeine Administration on Expression Ratio of Bax and Bcl-2 Proteins in Myocardial Tissue of Male Wistar Rats With Type 2 Diabetes

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2020
Objective: Some previous studies have shown the protective effect of caffeine on apoptosis through the regulation of pro- and anti-apoptotic proteins.
Ali Zarghami Khameneh, Saeed Nikookheslat, Afshar Jafari , Pouran Karimi   +3 more
doaj   +1 more source

Antiapoptotic and antioxidative effects of cerium oxide nanoparticles on the testicular tissues of streptozotocin-induced diabetic rats: An experimental study

International Journal of Reproductive BioMedicine, 2021
Background: Cerium dioxide nanoparticles (CNPs) due to the antidiabetic and antioxidant activities are proposed for the treatment of oxidative stress-associated diseases.
Torab Solgi, Iraj Amiri, Sara Soleimani Asl, Massoud Saidijam, Banafsheh Mirzaei Seresht, Tayebe Artimani   +5 more
doaj   +1 more source

Mcl-1 is a key regulator of the ovarian reserve [PDF]

, 2015
A majority of ovarian follicles are lost to natural death, but the disruption of factors involved in maintenance of the oocyte pool results in a further untimely follicular depletion known as premature ovarian failure.
Chi, M, Greenblatt, E, Jurisicova, A, Kim, K, Moley, K H, Naranian, T, Omari, S, Opferman, J T, Perumalsamy, A L, Waters, M   +9 more
core   +2 more sources

Reproductive status of male rat offspring following exposure to methamphetamine during intrauterine life: An experimental study

International Journal of Reproductive BioMedicine, 2023
Background: Methamphetamine abuse during pregnancy is associated with maternal and fetal adverse outcomes. Methamphetamine induces reproductive damage in adults; however, its effect has not been studied during pregnancy.
Zahra Khoshgoftar Some Saraii, Soroush Dianaty, Fatemeh Rouhollah, Nayereh Zare, Batool Ghorbani Yekta   +4 more
doaj   +1 more source

Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP) [PDF]

, 2010
Introduction Loss of corneal endothelial cells (CECs) is one major factor limiting transplant clarity and survival after keratoplasty. Amongst other factors, apoptosis due to cellular stress is responsible for these problems.
Hirneiß, Christoph, Kampik, Anselm, Kernt, Marcus, Neubauer, Aljoscha Steffen   +3 more
core   +3 more sources

Dissecting the pathways of tumour escape: " question of life and death?" Dissecando os caminhos de escape do tumor: "uma questão de vida e morte?"

Anais Brasileiros de Dermatologia, 2010
Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction
Georgi Tchernev, Pietro Nenoff
doaj   +1 more source

Impact of neurotrophic factors combination therapy on retinitis pigmentosa

Journal of International Medical Research, 2020
Objective We aimed to determine the location of neurotrophic receptors tropomyosin receptor kinase (Trk)B, TrkC, and ciliary neurotrophic factor receptor (CNTFR)α in the retina of retinal degeneration ( rd ) mice and to explore the dynamic changes of B ...
Xiaobei Yin, Ting He, Rui Chen, Hui Cui, Genlin Li   +4 more
doaj   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source