Results 41 to 50 of about 51,063 (266)

Cold dark matter and the LHC [PDF]

Journal of Physics G: Nuclear and Particle Physics, 2004
33 pages, 15 eps figures, J. Phys. G topical review (documentclass iopart)
Battaglia, Marco, Hinchliffe, Ian, Tovey, Daniel   +2 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Particle motion and QPOs around Euler-Heisenberg black hole immersed in cold dark matter halo

Nuclear Physics B
We explore the motion of particles in the vicinity of an Euler-Heisenberg black hole immersed in a cold dark matter halo, focusing on how the black hole parameters influence particle dynamics. This black hole solution is characterized by five parameters,
G. Mustafa, S.K. Maurya, Tayyab Naseer, Arzu Cilli, Ertan Güdekli, Assmaa Abd-Elmonem, Neissrien Alhubieshi   +6 more
doaj   +1 more source

Clumpy cold dark matter

The Astrophysical Journal, 1993
A study is conducted of cold dark matter (CDM) models in which clumpiness will inhere, using cosmic strings and textures suited to galaxy formation. CDM clumps of 10 million solar mass/cu pc density are generated at about z(eq) redshift, with a sizable fraction surviving.
Joseph Silk, Albert Stebbins
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Indirect Detection of Decaying Dark Matter with High Angular Resolution: The Case for Axion Search by IRCS on the Subaru Telescope

The Astrophysical Journal
Recent advances in photon detectors have provided exceptional sensitivities to dark matter with high angular resolution. Motivated by this, we present a detailed study of photon flux from dark matter decay in dwarf spheroidal galaxies (dSphs) by focusing
Wen Yin, Kohei Hayashi
doaj   +1 more source

The Signatures of Self-interacting Dark Matter and Subhalo Disruption on Cluster Substructure

The Astrophysical Journal, 2022
The abundance, distribution, and inner structure of satellites of galaxy clusters can be sensitive probes of the properties of dark matter. We run 30 cosmological zoom-in simulations with self-interacting dark matter (SIDM), with a velocity-dependent ...
Joy Bhattacharyya, Susmita Adhikari, Arka Banerjee, Surhud More, Amit Kumar, Ethan O. Nadler, Suchetana Chatterjee   +6 more
doaj   +1 more source

Warm Dark Matter in Simulations

Universe, 2022
In recent years, warm dark matter models have been studied as a viable alternative to the cold dark matter models. The warm dark matter particle properties are expected to imprint distinct signatures on the structure formation at both large and small ...
Sinziana Paduroiu
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source