Results 41 to 50 of about 5,186,076 (313)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

AT THE THRESHOLD OF MATURITY

open access: yesTASK Quarterly, 2005
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ANDRZEJ JANUSZAJTIS
doaj  

History and Sociology of Science [PDF]

open access: yes, 2018
The relationship between archaeology and other sciences has only recently become a research topic for sociologists and historians of science. From the 1950s to the present day, different approaches have been taken and the aims of research studies have changed considerably.
Delley, Géraldine, Plutniak, Sébastien
openaire   +3 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Department of History and Political Science Registration Newsletter Spring 2015 [PDF]

open access: yes, 2015
In this issue: Professor Allan Whitmore Lecture Portland Women’s History Trail app Registration information Scholarship recipients HTY/POS Courses Offered Fall 2015 HTY/POS Internships Offered Fall 2015 Department Newshttps://digitalcommons.usm.maine ...
Department of History and Political Science, University of Southern Maine
core   +7 more sources

THE LIBRARY OF THE TECHNICAL UNIVERSITY OF GDANSK IN BREMEN

open access: yesTASK Quarterly, 2002
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ANDRZEJ JANUSZAJTIS
doaj  

HISTORY OF SCIENCE: PROBLEMS AND PRACTICES. HISTORY OF SCIENCE(S), HISTORY OF MENTALITIES, MICRO-HISTORY [PDF]

open access: yesNuncius, 1983
L'article est le point de vue d'un historien de la science, Jacques Roger, a propos du statut institutionnel de l'histoire des sciences. Il affirme la necessite de donner une dimension nouvelle aux revolutions scientifiques en faveur d'une consideration plus attentive des decouvertes ponctuelles qui modifient localement une discipline scientifique.
openaire   +3 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

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