Results 41 to 50 of about 11,089 (193)

First‐trimester screening for pre‐eclampsia and small for gestational age: A comparison of the gaussian and Fetal Medicine Foundation algorithms

International Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 150-160, January 2023., 2023
Abstract Objective Pre‐eclampsia (PE) and small for gestational age (SGA) can be predicted from the first trimester. The most widely used algorithm worldwide is the Fetal Medicine Foundation (FMF) algorithm. The recently described Gaussian algorithm has reported excellent results although it is unlikely to be externally validated.
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia‐Manau, María Ángeles Sanchez‐Duran, María Pancorbo, Cristina Forcada, María Teresa Murcia, Ana Perestelo, Mireia Armengol‐Alsina, Manel Mendoza, Elena Carreras   +11 more
wiley   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

Advanced Science, EarlyView.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu, Kang Ning, Zhaohao Huang, Binyao Chen, Junjie Chen, Yingying Wen, Jian Bu, Han Hong, Qiaorong Chen, Zhuoqi Zhang, Renbing Jia, Wenru Su   +11 more
wiley   +1 more source

Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

Anais Brasileiros de Dermatologia, 2023
Cutaneous lupus erythematosus is an autoimmune disease of varied clinical expression, which may present as an exclusively cutaneous disease or be one of the multiple manifestations of systemic lupus erythematosus.
Everton Carlos Siviero do Vale, Lucas Campos Garcia   +1 more
doaj   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report

SAGE Open Medical Case Reports, 2020
Drug-induced lupus erythematosus has features distinct from primary systemic lupus erythematosus. It can occur with a wide variety of agents that result in the generation of anti-histone or other types of antibodies.
Umut Selamet, Ramy M Hanna, Anthony Sisk, Lama Abdelnour, Lena Ghobry, Ira Kurtz   +5 more
doaj   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 185-197, February 2023., 2023
Abstract Type 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β‐cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue‐localized delivery of therapeutic agents to restore endogenous β‐cell ...
Gregory P. Marshall, Judit Cserny, Chun‐Wei Wang, Benjamin Looney, Amanda L. Posgai, Rhonda Bacher, Benjamin Keselowsky, Todd M. Brusko   +7 more
wiley   +1 more source

Discoid Lupus Erythematosus of the Scalp in a Patient with Systemic Lupus Erythematosus: A Case Report with Complete Hair Regrowth

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2021
Scalp involvement with hair loss is common in systemic lupus erythematosus. Discoid lupus erythematosus may cause scarring alopecia, characterized by well-delimited erythematous plaques with scales, follicular hyperkeratosis and atrophy, which is ...
Cleide Garbelini-Lima, Gabriela Evangelista de Almeida, Sidharta Quércia Gabdelha, Andrea Cavalcante de Souza, Mara Lúcia Gomes de Souza, Virginia Vilasboas Figueiras   +5 more
doaj   +1 more source

Enhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases

Advanced Science, EarlyView.
This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.
Shiqiang Wang, Shiqing Liu, Jingfeng Zhang, Zhouyang Yu, Yifan Shao, Cong Zhao, Jiahong Ma, Xin Fu, Mengqi Yang, Lie Chen, Mingjie Liu, Li Wen   +11 more
wiley   +1 more source