Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. [PDF]
J Biol Chem, 2016 The BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Pro-apoptotic Bcl-2-associated X protein (BAX) is an executioner protein of the BCL-2 family that represents the gateway to mitochondrial apoptosis.
Uchime O +7 more
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Isolation of Synthetic Antibodies Against BCL-2-Associated X Protein (BAX). [PDF]
Methods Mol Biol, 2019 The BCL-2 protein family plays central roles in the mitochondrial pathway of cell apoptosis. The BCL-2-Associated X protein (BAX), along with other proapoptotic proteins, induces cell death in response to a variety of stress stimuli. Upon receipt of killing signals, cytosolic BAX is activated and translocates to mitochondria where it causes ...
Dai Z, Lai JR.
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The Chinese herb Prunella vulgaris promotes apoptosis in human well-differentiated thyroid carcinoma cells via the B-cell lymphoma-2/Bcl-2-associated X protein/caspase-3 signaling pathway. [PDF]
Oncol Lett, 2017 Prunella vulgaris (PV), a traditional Chinese herb, has been shown to be rich in bioactive chemicals and possess anti-proliferative and pro-apoptotic effects on tumor cells. The effect of PV on human well-differentiated thyroid carcinoma (WDTC), which accounts for the majority of common endocrine malignancies, remains to be elucidated.
Yin DT +8 more
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Knockdown of interleukin-6 plays a neuroprotective role against hypoxia-ischemia in neonatal rats via inhibition of caspase 3 and Bcl-2-associated X protein signaling pathway. [PDF]
Ibrain, 2022 AbstractThis study aimed to investigate the role of interleukin‐6 (IL‐6) in the pathogenesis of neonatal hypoxic‐ischemic encephalopathy (NHIE). Sprague‐Dawley (SD) rats were used for the establishment of hypoxic‐ischemic (HI) model. The Zea‐Longa scoring was used to evaluate the extent of the neurological deficits. Triphenyl tetrazolium chloride (TTC)
Yang X, Liao KH, Deng IB, Zhang LC.
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Long non-coding RNA SNHG1 mediates neuronal damage in Parkinson's disease model cells by regulating miR-216a-3p/Bcl-2-associated X protein. [PDF]
Ann Transl Med, 2021 Parkinson's disease (PD) is a common central nervous system degenerative disease in middle-aged and elderly people. Our study aimed to illuminate the relationship and mechanism of long-chain non-coding RNA SNHG1 and miRNA (miR)-216a-3p in PD.Human neuroblastoma cell lines were treated with MPP+ to construct a PD model.
Wang H +5 more
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Gene expression profiling ofliver X receptor αandBcl-2-associated X proteinin experimental transection spinal cord-injured rats [PDF]
The Journal of Spinal Cord Medicine, 2013 Study of molecular responses to central nervous system injury would be helpful for controlling the harmful pathways post-injury and triggering the useful pathways required for the treatment of injury.To investigate the expression level of liver X receptor α (LXRα) which has anti-inflammatory effects and pro-apoptotic Bcl-2-associated X protein (Bax ...
Esmat Mohammadi +3 more
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Bcl-2-Associated X Protein Is the Main Mediator of Manumycin A-Induced Apoptosis in Anaplastic Thyroid Cancer Cells [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2005 We previously demonstrated that the combination of paclitaxel and manumycin A, a farnesyltransferase inhibitor, enhanced apoptosis of anaplastic thyroid cancer (ATC) cells. However, the mechanism of the manumycin-induced apoptosis is not fully understood.
Jingxuan Pan +4 more
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Molecular Medicine Reports, 2015 Ginsenoside Rg3 is one of the main constituents isolated from Panax ginseng, and exhibits cytotoxic effects against cancer cells. The present study aimed to investigate the effects of ginsenoside Rg3 on human multiple myeloma cells, and determine the underlying molecular mechanisms. The cells were exposed to ginsenoside Rg3 at various concentrations (0‑
Yun Luo +4 more
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Journal of Traditional Chinese Medicine, 2013 To study on effects of Lichong decoction on expression of apoptosis-controlling genes, Bcl-2 and Bcl-2-associated X protein (Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.Fifty Wistar female rats were randomly divided into a normal group, a model group, a Lichong decoction group, a Guizifuling capsule group and a Mifepristone group ...
Donghua Li +7 more
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Diazepam ameliorated myocardial ischemia-reperfusion injury via inhibition of C-C chemokine receptor type 2/tumor necrosis factor-alpha/interleukins and Bcl-2-associated X protein/caspase-3 pathways in experimental rats. [PDF]
J Vet Med Sci, 2021 Myocardial ischemia-reperfusion injury (IRI) is one of the most leading concerns for public health globally. Diazepam, a local anesthetic, has been reported for its cardioprotective potential. The present investigation aimed to evaluate the possible mechanism of action of diazepam against left anterior descending ligation-induced myocardial IRI in ...
Jiang T, Ma X, Chen H, Jia H, Xiong Y.
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