Results 1 to 10 of about 104,089 (117)

Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes [PDF]

arXiv, 2008
Many types of tumors exhibit chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletionsare also observed. Typically, a region that is aberrant in more tumors,or whose copy number change is stronger, would be considered as a more promising candidate to be ...
Domany, Eytan, Hegi, Monika E., Lambiv, Wanyu L., Reiner, Anat, Shay, Tal   +4 more
arxiv   +7 more sources

Uncovering Proximity of Chromosome Territories using Classical Algebraic Statistics [PDF]

arXiv, 2014
Exchange type chromosome aberrations (ETCAs) are rearrangements of the genome that occur when chromosomes break and the resulting fragments rejoin with other fragments from other chromosomes. ETCAs are commonly observed in cancer cells and in cells exposed to radiation.
Arsuaga, Javier, Heskia, Ido, Hosten, Serkan, Maskalevich, Tatsiana   +3 more
arxiv   +3 more sources

Alpha-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro show evidence of emerging genomic instability [PDF]

, 2015
Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources.
A Duran, AA Edwards, BD Loucas, CA Whitehouse, CL Limoli, CS Griffin, D Becker, DL Henshaw, DT Goodhead, DT Goodhead, Dudley T. Goodhead, EG Wright, Ester Hammond, FE Alexander, FK Kong, G Kendall, GB Curwen, GB Curwen, GE Watson, GE Watson, H Jadvar, H Nikjoo, HA Foster, HG Paretzke, HT Petrie, I, J Sevc, JD Harrison, JE Moquet, JM Samet, JR Savage, KA George, KL Johnson, KM Greulich, L Al-Harthi, LG Littlefield, M Ahmad, M Durante, M Kadhim, M Themis, MA Kadhim, MA Kadhim, MA Kadhim, MA Kadhim, MA Kadhim, MD Hazenberg, MJ Ramsey, MN Cornforth, MR Speicher, Natalia Sumption, NV Sotnik, RF Hobbs, Rhona M. Anderson, RM Anderson, RM Anderson, RM Anderson, RM Anderson, RM Anderson, S Bonassi, S Chakraborty, S Darby, S Darby, T Lapidot, W Friedland, W Vuong, WF Morgan, Y Kodama   +66 more
core   +6 more sources

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes [PDF]

, 1988
Repeated DNAs from the constitutive heterochromatin of human chromosomes 1 and 18 were used as probes in nonradioactive in situ hybridization experiments to define specific numerical and structural chromosome aberrations in three human glioma cell lines ...
A.H.N. Hopman, Atkin, Bigner, Brigati, Burns, Burns, Carine, Cavenee, Comings, Cooke, Cooke, Cremer, D. Tesin, Dale, Devilee, Devilee, Dudin, Durnam, Gosden, Hadlaczky, Hall, Henn, Higgins, Hopman, Hopman, Hopman, Hopman, Hopman, Joseph, Julien, Kinzler, Kohl, L. Manuelidis, Landegent, Landegent, Langer-Safer, Leary, Lund Jorgensen, Maniatis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Manuelidis, McDermid, Müller, Müncke, Pinkel, Pinkel, Rappold, Schardin, Schwab, Shapiro, Siegel, T. Cremer, Therman, Trask, Willard, Wu, Yang   +64 more
core   +1 more source

Reduced chromosome aberration complexity in normal human bronchial epithelial cells exposed to low-LET γ-rays and high-LET α-particles [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund.Copyright © 2013 The Author(s). Purpose: Cells of the lung are at risk from exposure to low and moderate doses of ionizing radiation from a range of environmental and medical ...
Anderson, RM, Garimberti, E, Hill, MA, Themis, M   +3 more
core   +2 more sources

Accurate chromosome segregation by probabilistic self-organization [PDF]

BMC Biology 2015 13:65, 2014
Background: For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-orientation). Incorrect attachments of kinetochore microtubules (kMTs) lead to chromosome mis-segregation and aneuploidy, which is often
arxiv   +1 more source

No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5’-bromodeoxyuridine [PDF]

, 2006
The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and determination of cell cycle status.
Anderson, Anderson, Anderson, Anderson, Boei, Cornforth, Dresp, Dudley T. Goodhead, Edwards, George, Goodhead, Griffin, Hawkins, Hsu, Iliakis, Kolin-Gerresheim, Latt, Leonard, Lloyd, Lorimore, Lucas, Moquet, Morimoto, Morton, Natalia D. Sumption, Pala, Perry, Ramsey, Rhona M. Anderson, Ritter, Sachs, Savage, Savage, Schmid, Scott, Simpson, Singleton, Tice, Wang   +38 more
core   +1 more source

Masked conditional variational autoencoders for chromosome straightening [PDF]

arXiv, 2023
Karyotyping is of importance for detecting chromosomal aberrations in human disease. However, chromosomes easily appear curved in microscopic images, which prevents cytogeneticists from analyzing chromosome types. To address this issue, we propose a framework for chromosome straightening, which comprises a preliminary processing algorithm and a ...
arxiv  

Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Christoph, Cremer, Thomas, Emmerich, Patricia, Lichter, Peter, Popp, Susanne   +4 more
core   +1 more source

Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control [PDF]

Eur. Phys. J. D 73, 64 (2019), 2019
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains in microscopic and macroscopic spatio-temporal landscapes, i.e., stochastic birth-death processes of cells in ...
arxiv   +1 more source