Results 1 to 10 of about 391,284 (388)

E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin

Cell & Bioscience, 2022
Background Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment.
Weixiang Song, Danchen Zhang, Jiaqi Mi, Wenfei Du, Yang Yang, Rong Chen, Cong Tian, Xiaodong Zhao, Kang Zou   +8 more
doaj   +1 more source

Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Communications Biology, 2023
Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and ...
Ritsuko Suyama, Nicolas Cetraro, Joanne Y. Yew, Toshie Kai   +3 more
doaj   +1 more source

Next-Generation Sequencing of DDX41 in Myeloid Neoplasms Leads to Increased Detection of Germline Alterations

Frontiers in Oncology, 2021
Previously considered rare, inherited hematologic malignancies are increasingly identified. Germline mutations in the RNA helicase DDX41 predispose to increased lifetime risks of myeloid neoplasms with disease often occurring later in life which presents
Sarah A. Bannon, Mark J. Routbort, Guillermo Montalban-Bravo, Rohtesh S. Mehta, Fatima Zahra Jelloul, Koichi Takahashi, Naval Daver, Betul Oran, Naveen Pemmaraju, Gautam Borthakur, Kiran Naqvi, Ghayas Issa, Koji Sasaki, Yesid Alvarado, Tapan M. Kadia, Marina Konopleva, Rashmi Kanagal Shamanna, Joseph D. Khoury, Farhad Ravandi, Richard Champlin, Hagop M. Kantarjian, Kapil Bhalla, Guillermo Garcia-Manero, Keyur P. Patel, Courtney D. DiNardo   +24 more
doaj   +1 more source

Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis [PDF]

, 2020
The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T.
Bublys, Kasparas, Chen, Hwei-Yen, Immler, Simone, Jolly, Cecile, Marcu, Daniel   +4 more
core   +1 more source

A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State

Cell & Bioscience, 2023
Background The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the ...
Rui Wei, Xiaoyu Zhang, Xiaoxiao Li, Jian Wen, Hongyang Liu, Jiqiang Fu, Li Li, Wenyi Zhang, Zhen Liu, Yang Yang, Kang Zou   +10 more
doaj   +1 more source

Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

eLife, 2022
Maternally synthesized products play critical roles in the development of offspring. A premier example is the Caenorhabditis elegans H3K36 methyltransferase MES-4, which is essential for germline survival and development in offspring.
Chad Steven Cockrum, Susan Strome
doaj   +1 more source

Progress in germline stem cell transplantation in mammals and the potential usage

Reproductive Biology and Endocrinology, 2022
Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation.
Wen Zhang, Ruotian Nie, Yihui Cai, Wenhai Xie, Kang Zou   +4 more
doaj   +1 more source

Case report: Two sisters with a germline CHEK2 variant and distinct endocrine neoplasias

Frontiers in Endocrinology, 2022
Genetic testing has become the standard of care for many disease states. As a result, physicians treating patients who have tumors often rely on germline genetic testing results for making clinical decisions.
Raphaelle D. Vallera, Yanli Ding, Kimmo J. Hatanpaa, Justin A. Bishop, Sasan Mirfakhraee, Abdel A. Alli, Sergei G. Tevosian, Mouna Tabebi, Mouna Tabebi, Oliver Gimm, Peter Söderkvist, Peter Söderkvist, Cynthia Estrada-Zuniga, Patricia L. M. Dahia, Hans K. Ghayee   +14 more
doaj   +1 more source

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]

, 2020
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat, Ambrozkiewicz, Mateusz C, Beier, Kevin T, Benseler, Fritz, Brose, Nils, Burgess, Harold A, Cepko, Constance L, Chen, Cui, Cloutier, Jean-François, Craig, Ann Marie, Dumontier, Emilie, Eroglu, Cagla, Falkner, Susanne, Furlanis, Elisabetta, Goebbels, Sandra, Gomez, Andrea M, Hoshina, Naosuke, Huang, Wei-Hsiang, Hutchison, Mary Anne, Itoh-Maruoka, Yu, Kaeser, Pascal S, Kawabe, Hiroshi, Kay, Jeremy N, Lavery, Laura A, Li, Wei, Lu, Wei, Luo, Lin, Luo, Liqun, Mandai, Kenji, Maruo, Tomohiko, McBain, Chris J, Motohashi, Junko, Nave, Klaus-Armin, Pai, Emily Ling-Lin, Pelkey, Kenneth A, Pereira, Ariane, Philips, Thomas, Prado, Marco AM, Prado, Vania F, Rothstein, Jeffrey, Rubenstein, John LR, Saher, Gesine, Sakimura, Kenji, Sanes, Joshua R, Scheiffele, Peter, Sinclair, Jennifer L, Stogsdill, Jeff A, Takai, Yoshimi, Traunmüller, Lisa, Umemori, Hisashi, Verhage, Matthijs, Wang, Jiexin, Wortel, Joke, You, Wenjia, Yuzaki, Michisuke, Zoghbi, Huda Yahya   +55 more
core   +2 more sources

The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis

Open Biology, 2021
A feature of metazoan reproduction is the elimination of maternal centrosomes from the oocyte. In animals that form syncytial cysts during oogenesis, including Drosophila and human, all centrosomes within the cyst migrate to the oocyte where they are ...
Alexis Leah Braun, Francesco Meghini, Gema Villa-Fombuena, Morgane Guermont, Elisa Fernandez-Martinez, Zhang Qian, Maria Dolores Martín-Bermudo, Acaimo González-Reyes, David Moore Glover, Yuu Kimata   +9 more
doaj   +1 more source