Results 1 to 10 of about 16,602 (182)
m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma
Frontiers in Genetics, 2022 Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...Ying Gan, Ying Gan, Aolin Li, Aolin Li, Jun Liu, Jun Liu, Xiaofei Wang, Xiaofei Wang, Zhenan Zhang, Zhenan Zhang, Qinhan Li, Qinhan Li, Xiongjun Ye, Xiongjun Ye, Lin Yao, Lin Yao, Qian Zhang, Qian Zhang +17 moredoaj +1 more sourceSingle-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction
Frontiers in Endocrinology, 2022 PurposeTo assess the diverse cell populations of human corpus cavernosum in patients with severe erectile dysfunction (ED) at the single-cell level.MethodsPenile tissues collected from three patients were subjected to single-cell RNA sequencing using the Dong Fang, Dong Fang, Dong Fang, Xiao-Hui Tan, Xiao-Hui Tan, Xiao-Hui Tan, Wen-Peng Song, Wen-Peng Song, Wen-Peng Song, Yang-Yang Gu, Yang-Yang Gu, Yang-Yang Gu, Jian-Cheng Pan, Jian-Cheng Pan, Xiao-Qing Yang, Xiao-Qing Yang, Wei-Dong Song, Wei-Dong Song, Wei-Dong Song, Yi-Ming Yuan, Yi-Ming Yuan, Yi-Ming Yuan, Jing Peng, Jing Peng, Jing Peng, Zhi-Chao Zhang, Zhi-Chao Zhang, Zhi-Chao Zhang, Zhong-Cheng Xin, Zhong-Cheng Xin, Xue-Song Li, Xue-Song Li, Xue-Song Li, Rui-Li Guan, Rui-Li Guan, Rui-Li Guan +35 moredoaj +1 more sourceTRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma
Journal of Experimental & Clinical Cancer Research, 2023 Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation of key molecular mechanisms of ...Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou, Kan Gong +11 moredoaj +1 more sourceSkimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “Salting-Out”: Characterizations and Potential Functions as Nanocarriers
Frontiers in Nutrition, 2021 Bovine milk-derived extracellular vesicles (BM-EVs) are recognized as promising nanoscale delivery vectors owing to their large availability. However, few isolation methods can achieve high purity and yield simultaneously. Therefore, we developed a novel Xiao-Hui Tan, Xiao-Hui Tan, Xiao-Hui Tan, Dong Fang, Dong Fang, Dong Fang, Yong-De Xu, Tie-Gui Nan, Wen-Peng Song, Wen-Peng Song, Wen-Peng Song, Yang-Yang Gu, Yang-Yang Gu, Yang-Yang Gu, Sheng-Ji Gu, Sheng-Ji Gu, Sheng-Ji Gu, Yi-Ming Yuan, Yi-Ming Yuan, Yi-Ming Yuan, Zhong-Cheng Xin, Zhong-Cheng Xin, Zhong-Cheng Xin, Li-Qun Zhou, Li-Qun Zhou, Li-Qun Zhou, Rui-Li Guan, Rui-Li Guan, Rui-Li Guan, Xue-Song Li, Xue-Song Li, Xue-Song Li +31 moredoaj +1 more sourceSilencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma
Frontiers in Molecular Biosciences, 2021 To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with ...Ying Gan, Ying Gan, Ying Gan, Congcong Cao, Aolin Li, Aolin Li, Aolin Li, Haifeng Song, Haifeng Song, Haifeng Song, Guanyu Kuang, Guanyu Kuang, Guanyu Kuang, Binglei Ma, Binglei Ma, Binglei Ma, Quan Zhang, Quan Zhang, Quan Zhang, Qian Zhang, Qian Zhang, Qian Zhang +21 moredoaj +1 more sourceCancer immunotherapies: advances and bottlenecks
Frontiers in Immunology, 2023 Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host immune system to provide passive or active immunity against malignant tumors ...Rui Rui, Rui Rui, Rui Rui, Rui Rui, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou, Shiming He, Shiming He, Shiming He, Shiming He +11 moredoaj +1 more sourceTranscriptome-Wide Map of N6-Methyladenosine Methylome Profiling in Human Bladder Cancer
Frontiers in Oncology, 2021 N6-Methyladenosine (m6A) is the most widespread internal RNA modification in several species. In spite of latest advances in researching the biological roles of m6A, its function in the development and progression of bladder cancer remains unclear.Aolin Li, Aolin Li, Aolin Li, Aolin Li, Ying Gan, Ying Gan, Ying Gan, Ying Gan, Congcong Cao, Binglei Ma, Binglei Ma, Binglei Ma, Binglei Ma, Quan Zhang, Quan Zhang, Quan Zhang, Quan Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Lin Yao, Lin Yao, Lin Yao, Lin Yao +24 moredoaj +1 more sourceAdvances in the research of exosomes in renal cell carcinoma: from mechanisms to applications
Frontiers in Immunology, 2023 Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC.Rui Rui, Rui Rui, Rui Rui, Rui Rui, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou, Shiming He, Shiming He, Shiming He, Shiming He +11 moredoaj +1 more sourceIdentification of the Six-RNA-Binding Protein Signature for Prognosis Prediction in Bladder Cancer
Frontiers in Genetics, 2020 RNA-binding proteins (RBPs) are a kind of gene regulatory factor that presents a significant biological effect in the initiation and development of various tumors, including bladder cancer (BLCA).Yucai Wu, Yucai Wu, Yucai Wu, Yucai Wu, Yi Liu, Anbang He, Anbang He, Anbang He, Anbang He, Bao Guan, Bao Guan, Bao Guan, Bao Guan, Shiming He, Shiming He, Shiming He, Shiming He, Cuijian Zhang, Cuijian Zhang, Cuijian Zhang, Cuijian Zhang, Zhengjun Kang, Yanqing Gong, Yanqing Gong, Yanqing Gong, Yanqing Gong, Xuesong Li, Xuesong Li, Xuesong Li, Xuesong Li, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou +33 moredoaj +1 more sourceIcariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway
Frontiers in Pharmacology, 2022 Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing a central role in numerous vascular diseases.Yang-Yang Gu, Yang-Yang Gu, Yang-Yang Gu, Xiao-Hui Tan, Xiao-Hui Tan, Xiao-Hui Tan, Wen-Peng Song, Wen-Peng Song, Wen-Peng Song, Wei-Dong Song, Wei-Dong Song, Wei-Dong Song, Yi-Ming Yuan, Yi-Ming Yuan, Yi-Ming Yuan, Zhong-Cheng Xin, Zhong-Cheng Xin, Jia-Dong Wang, Dong Fang, Dong Fang, Dong Fang, Rui-Li Guan, Rui-Li Guan, Rui-Li Guan +23 moredoaj +1 more source