Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. [PDF]
PLoS ONE, 2012 Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
Sophie R Thomson +6 more
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Motor neurons and the generation of spinal motor neurons diversity [PDF]
Frontiers in Cellular Neuroscience, 2014 Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate.
Nicolas eStifani
doaj +4 more sources
Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization [PDF]
eLifeSensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt +9 more
doaj +2 more sources
Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes
eLife, 2023 Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel +7 more
doaj +1 more source
DeckerMed Neurology, 2022 The motor neuron diseases (MNDs) are a family of diseases commonly categorized by their propensity to affect upper or lower motor neurons and by their mode of inheritance. The chapter provides some content on infectious MNDs caused by viral infections affecting the motor neurons in the anterior horn of the spinal cord. However, the chapter devotes most
Elena Ratti +2 more
openaire +1 more source
A size principle for recruitment of Drosophila leg motor neurons
eLife, 2020 To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control ...
Anthony W Azevedo +5 more
doaj +1 more source
Motor neurons in the escape response circuit of white shrimp (Litopenaeus setiferus) [PDF]
PeerJ, 2015 Many decapod crustaceans perform escape tailflips with a neural circuit involving giant interneurons, a specialized fast flexor motor giant (MoG) neuron, populations of larger, less specialized fast flexor motor neurons, and fast extensor motor neurons ...
Zen Faulkes
doaj +2 more sources
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]
, 2020 In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana +36 more
core +1 more source
Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect. [PDF]
PLoS ONE, 2018 The stick insect is a well-established experimental animal to study the neural basis of walking. Here, we introduce a preparation that allows combining calcium imaging in efferent neurons with electrophysiological recordings of motor neuron activity in ...
Jens Goldammer +3 more
doaj +1 more source
JCI Insight, 2023 Spinal motor neurons have been implicated in the loss of motor function that occurs with advancing age. However, the cellular and molecular mechanisms that impair the function of these neurons during aging remain unknown. Here, we show that motor neurons
Ryan W. Castro +3 more
doaj +1 more source