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The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

Frontiers in Cellular and Infection Microbiology, 2022
Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the human nasopharynx. It shares and competes for this niche with a number of other Neisseria species including N. lactamica, N. cinerea and N. mucosa.
August Mikucki, Nicolie R. McCluskey, Nicolie R. McCluskey, Charlene M. Kahler   +3 more
doaj   +2 more sources

Commensal Neisseria cinerea impairs Neisseria meningitidis microcolony development and reduces pathogen colonisation of epithelial cells.

PLoS Pathogens, 2020
It is increasingly being recognised that the interplay between commensal and pathogenic bacteria can dictate the outcome of infection. Consequently, there is a need to understand how commensals interact with their human host and influence pathogen ...
Rafael Custodio, Errin Johnson, Guangyu Liu, Christoph M Tang, Rachel M Exley   +4 more
doaj   +2 more sources

Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]

PLoS ONE, 2011
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hazel En En Wong, Ming-Shi Li, J Simon Kroll, Martin L Hibberd, Paul R Langford   +4 more
doaj   +4 more sources

Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.

PLoS ONE, 2015
Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis.
Barbara Bottazzi, Laura Santini, Silvana Savino, Marzia M Giuliani, Ana I Dueñas Díez, Giuseppe Mancuso, Concetta Beninati, Marina Sironi, Sonia Valentino, Livija Deban, Cecilia Garlanda, Giuseppe Teti, Mariagrazia Pizza, Rino Rappuoli, Alberto Mantovani   +14 more
doaj   +2 more sources

Antimicrobial-Resistant Clonal Complex 11 Neisseria meningitidis–Associated Urethritis Cluster, Thailand [PDF]

Emerging Infectious Diseases
Sexually transmitted infections clinics in Bangkok, Thailand, reported increasing numbers of men with Neisseria meningitidis–associated urethritis during 2017–2023.
John C. Cartee, Thitima Cherdtrakulkiat, Sandeep J. Joseph, Rossaphorn Kittiyaowamarn, Natnaree Girdthep, Pongsathorn Sangprasert, Porntip Paopang, Thidathip Wongsurawat, Piroon Jenjaroenpun, Perapon Nitayanon, Rebekah Frankson, Silvina Masciotra, Teodora Wi, Ismael Maatouk, Ellen N. Kersh, Andrey S. Borisov, Chanwit Tribuddharat   +16 more
doaj   +2 more sources

Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis [PDF]

Emerging Infectious Diseases
We explored the role of commensal Neisseria in the emergence of third-generation cephalosporin-resistant N. meningitidis. Cefotaxime resistance–conferring penA795 was prevalent among commensal Neisseria isolates in Shanghai, China, and was acquired by a
Youxing Shao, Mingliang Chen, Jiehao Cai, Yohei Doi, Min Chen, Minggui Wang, Mei Zeng, Qinglan Guo   +7 more
doaj   +2 more sources

Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection

Nature Communications, 2018
Carriage of Neisseria lactamica, a harmless coloniser of the human respiratory tract, is inversely correlated with Neisseria meningitidis infection. Here, Pandey et al. provide insights into micro-evolutionary processes in N.
Anish K Pandey, David W Cleary, Jay R Laver   +2 more
exaly   +2 more sources

Rifampin-resistant Neisseria meningitidis

Emerging Infectious Diseases, 2006
To the Editor: Immediate management of meningococcal disease requires antimicrobial drug treatment of patients with β-lactams and chemoprophylaxis of contact persons with rifampin. High-level resistance to rifampin (MIC >32 mg/L) in Neisseria meningitidis is provoked by mutations (most frequently at the residue His 552) in the rpoB gene encoding the b ...
Muhamed-Kheir Taha, Maria Leticia Zarantonelli, Corinne Ruckly, Dario Giorgini, Jean-Michel Alonso   +4 more
doaj   +3 more sources

Neisseria Meningitidis Carriage Among Hajj and Umrah Pilgrims: A Systematic Review and Meta-Analysis [PDF]

European Journal of Medical Research
Background Meningococcal meningitis (MM), which is caused by the bacterium Neisseria meningitidis, represents a considerable public health concern during the Hajj and Umrah pilgrimages.
Raghad Alhajaji, Manal Alfahmi, Sadin Ayman Alamri, Aseel Ayman Alamri, Khalid Al Sulaiman, Sulaiman Ibrahim Alsugair, Hadeel Adel Alsulimani   +6 more
doaj   +2 more sources

Design of New Primer Sets for the Development of a Loop-Mediated Isothermal Amplification for Rapid Detection of Neisseria meningitidis [PDF]

Current Issues in Molecular Biology
Neisseria meningitidis is a pathogenic bacterial agent that causes meningococcal meningitis in humans. Developing a rapid and low-cost N. meningitidis detection method is crucial, especially for developing countries. This study focuses on the development
Cuong Viet Vo, Trang Thu Nguyen, Huong Thu Ngo, Lan Anh Thi Bui, Toan Van Trinh, Loan Thi Vu, Hieu Dang Hoang, Phong Quoc Truong   +7 more
doaj   +2 more sources