Results 1 to 10 of about 526,955 (247)

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

open access: yesNature Communications, 2022
Possible distinct contributions of Runx 2 and Runx3 in osteoarthritis have not been clarified. Nagata et al. show that Runx3 protects adult articular cartilage by extracellular matrix protein production in normal conditions, while Runx2 exerts both ...
Kosei Nagata   +21 more
doaj   +1 more source

Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human

open access: yesStem Cell Research & Therapy, 2021
Background Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of stem cells are thought as promising features for cartilage therapy; however, the ...
Chijimatsu Ryota   +17 more
doaj   +1 more source

Characteristics of three-dimensional acetabular morphology of patients with excellent outcome after rotational acetabular osteotomy over 20 years

open access: yesJournal of Orthopaedic Surgery and Research, 2021
Background Rotational acetabular osteotomy (RAO) is a type of pelvic osteotomy performed to improve the acetabular bony coverage against the femoral head for patients with acetabular dysplasia.
Takeyuki Tanaka   +5 more
doaj   +1 more source

Implementation of relative phase analysis to evaluate continuous interlimb coordination and stability in individuals with lower limb loss: Design and protocol for a retrospective analysis

open access: yesBMJ Open, 2023
Introduction The number of people with lower limb loss continues to grow, though most research to date has been non-committal and lacks the appropriate clinical guidance required for proper prosthetic prescription.
Alexis N Sidiropoulos   +2 more
doaj   +1 more source

Failure of preventive treatments in migraine: an observational retrospective study in a tertiary headache center

open access: yesBMC Neurology, 2020
Background Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs.
Marianna Delussi   +4 more
doaj   +1 more source

Pathomechanism of intervertebral disc degeneration

open access: yesJOR Spine, 2020
Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting ...
Takeshi Oichi   +4 more
doaj   +1 more source

Easily-Deployable Acoustic Local Positioning System Based on Auto-Calibrated Wireless Beacons

open access: yesSensors, 2019
Self-calibrated Acoustic Local Positioning Systems (ALPS) generally require a high consumption of hardware and software resources to obtain the user’s position at an acceptable update rate.
José A. Moreno   +3 more
doaj   +1 more source

Sensitive and selective phenol sensing in denitrifying Aromatoleum aromaticum EbN1T

open access: yesMicrobiology Spectrum, 2023
Aromatoleum aromaticum EbN1T anaerobically degrades phenol, p-cresol, and p-ethylphenol, each via a distinct peripheral pathway. The compound-specific regulation of each pathway is proposed to occur on the transcriptional level in the case of phenol ...
Ramona Buschen   +9 more
doaj   +1 more source

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