Results 31 to 40 of about 439,504 (253)

Positive Solutions of singular semilinear elliptic equation in bounded NTA- Domains [PDF]

open access: yes, 2020
We study the existence, the uniqueness and the sharp estimate of a positive solution of the nonlinear equation $$ \Delta v +\psi(.,v)=0,$$ in a bounded NTA-domain $\Omega$ in $\mathbb{R}^n \; (n\geq 2)$, when a measurable function $\psi(.,.)$ is ...
Ben Boubaker, M.A.
core   +1 more source

Die Vergleichsmessung 1997 für Radongasmessgeräte am PSI [PDF]

open access: yes, 1998
Vom 14. bis 20. Nov. 1997 führte das Referenzlabor für Radongas-Konzentrationsmessungen des Paul Scherrer Instituts die Vergleichsmessung 1997 für Radongasdetektoren und -messgeräte durch. An der Exposition in einer Referenzatmosphäre der PSI-Radonkammer
Christoph Schuler   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Fredholmness of multiplication of a weighted composition operator with its adjoint on H 2 $H^{2}$ and A α 2 $A_{\alpha}^{2}$

open access: yesJournal of Inequalities and Applications, 2018
In this paper, we obtain that C ψ , φ ∗ $C_{\psi,\varphi}^{\ast}$ is bounded below on H 2 $H^{2}$ or A α 2 $A_{\alpha}^{2}$ if and only if C ψ , φ $C_{\psi,\varphi }$ is invertible. Moreover, we investigate the Fredholm operators C ψ 1 , φ 1 C ψ 2 , φ 2 ∗
Mahmood Haji Shaabani
doaj   +1 more source

UCN, the ultracold neutron source - neutrons for particle physics [PDF]

open access: yes, 2021
Ultracold neutrons provide a unique tool for the study of neutron properties. An overview is given of the ultracold neutron (UCN) source at PSI, which produces the highest UCN intensities to fundamental physics experiments by exploiting the high ...
Lauss, Bernhard (author)   +1 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

Approximation Algorithm for the Minimum Hub Cover Set Problem

open access: yesIEEE Access, 2022
A subset ${\mathcal{ S}}\subseteq V$ of vertices of an undirected graph $G=(V,E)$ is a hub cover when for each edge $(u,v) \in E$ , at least one of its endpoints belongs to ${\mathcal{ S}}$ , or there exists a vertex $r \in {\mathcal{ S}}$ that ...
Joel A. Trejo-Sanchez   +3 more
doaj   +1 more source

Single and Double Knockouts of the Genes for Photosystem I Subunits G, K, and H of Arabidopsis [PDF]

open access: yes, 2002
Photosystem I (PSI) of higher plants contains 18 subunits. Using Arabidopsis En insertion lines, we have isolated knockout alleles of the genes psaG, psaH2, and psaK, which code for PSI-G, -H, and -K.
Varotto, Claudio   +7 more
core   +1 more source

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