Results 21 to 30 of about 449,355 (209)

Positive Solutions of singular semilinear elliptic equation in bounded NTA- Domains [PDF]

, 2020
We study the existence, the uniqueness and the sharp estimate of a positive solution of the nonlinear equation $$ \Delta v +\psi(.,v)=0,$$ in a bounded NTA-domain $\Omega$ in $\mathbb{R}^n \; (n\geq 2)$, when a measurable function $\psi(.,.)$ is ...
Ben Boubaker, M.A.
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Neutral set differential equations [PDF]

, 2015
summary:The aim of this paper is to establish an existence and uniqueness result for a class of the set functional differential equations of neutral type\begin {equation*} \begin {cases} D_{H}X(t)=F(t,X_{t},D_{H}X_{t}), \\ \kern .25em X|_{[-r,0]}=\Psi , \
O'Regan, Donald, O’Regan, Donald, Abbas, Umber, Younus, Awais, Lupulescu, Vasile   +4 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Die Vergleichsmessung 1997 für Radongasmessgeräte am PSI [PDF]

, 1998
Vom 14. bis 20. Nov. 1997 führte das Referenzlabor für Radongas-Konzentrationsmessungen des Paul Scherrer Instituts die Vergleichsmessung 1997 für Radongasdetektoren und -messgeräte durch. An der Exposition in einer Referenzatmosphäre der PSI-Radonkammer
Christoph Schuler, Butterweck-Dempewolf, Gernot (author), Gernot Butterweck-Dempewolf, Schuler, Christoph (author)   +3 more
core   +1 more source

UCN, the ultracold neutron source - neutrons for particle physics [PDF]

, 2021
Ultracold neutrons provide a unique tool for the study of neutron properties. An overview is given of the ultracold neutron (UCN) source at PSI, which produces the highest UCN intensities to fundamental physics experiments by exploiting the high ...
Lauss, Bernhard (author), Blau, Bertrand (author)   +1 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source