Results 241 to 250 of about 1,064,749 (319)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Isoflurane causes muscle contraction in <i>Drosophila melanogaster</i> despite inducing hyperpolarized state. [PDF]

MicroPubl Biol
Griffith J, Kim J, Cooper R.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Activation of 5-HT1A autoreceptors causes actin depolymerization in <i>Drosophila</i> serotonergic neurons. [PDF]

MicroPubl Biol
Kinser A, Rhodes JK, Roossien DH.
europepmc   +1 more source

Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonicsegments for bladder augmentation: in vivo, long term, and functional pilot study

, 2015
Hidas, Guy, Lee, Hak J, Bahoric, Andrej, Kelly, Maryellen S, Watts, Blake, Liu, Zhongbo, Saharti, Samah, Lusch, Achim, Alamsahebpour, Alireza, Kerbl, David, Truong, Hung, Zi, Xiaolin, Khoury, Antoine E   +12 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Development of pXeDNA3.1-LacZ, a Dual-System Plasmid for Membrane Protein Expression in <i>Xenopus</i> and Mammalian Cells. [PDF]

MicroPubl Biol
Guan L, Reynoldson TE, Pieroni EM, Dillon JC, Hardege I, Yanez-Guerra LA.   +5 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Discovery of Widespread Migrasome Formation During Amoeboid Migration in <i>Dictyostelium discoideum</i>. [PDF]

MicroPubl Biol
Plude BK, Damer CK.
europepmc   +1 more source