Results 101 to 110 of about 2,663,937 (342)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

The Model of Solving Ethnic Conflicts from the Perspective of the Holy Qur’an [PDF]

open access: yesاسلام و مطالعات اجتماعی
One of the challenges that human societies, especially multi-ethnic countries, including Islamic countries, have faced since ancient times is ethnic conflicts in racial, cultural and political aspects.
mohammad nasim jafari   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Some aspects of the ethnical identity of Serbs in Kosovo and Metohia: Focus on the North of province [PDF]

open access: yesBaština, 2013
In this paper the specificities of ethnic identity of Serbs in Kosovo and Metohia, and first of all, in the Northern part of Kosovska Mitrovica - the town which still represents the trigger of ethnic conflicts are presented.
Aritonović Ivana
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Introduction: Racial and Ethnic Conflict and Violence

open access: yesInternational Journal of Conflict and Violence, 2009
Racial and ethnic violence takes many forms. Genocides, ethnic cleansing, pogroms, civil wars, and violent separatist movements are the most obvious and extreme expressions, but less organized violence such as rioting, and hate crimes by individuals or ...
Werner Bergmann, Robert D. Crutchfield
doaj   +1 more source

[Review of] Milton J. Esman (Ed.), Ethnic Conflict in the Western World [PDF]

open access: yes, 1978
Ethnic conflict has reemerged in the economic and political arenas of the western world, less between nation states, more within the boundaries of particular nations.
Frye, Hardy T.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Topological socio-cultural evolution a predictor of ethnic conflicts in multi-ethnic societies [PDF]

open access: yes, 2014
Ethnic conflicts have been one of the biggest single threats for the progress of collaborative human societies. Ethnic issues are common to most multi-ethnic societies. Some of the conflicts are violent and damaging but not all are negative. Owing to the
Muthusamy, Paramasivam   +2 more
core  

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