Results 181 to 190 of about 12,390,722 (231)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bipolar Disorder and Perimenopause: An Update. [PDF]

Bipolar Disord
Radosavljevic J, Bengi D, Frey BN.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature. [PDF]

Rev Med Virol
Manders IG, van Tuinen EL, Weisfelt M, Goeijenbier M, Kalpoe JS, van Lelyveld SFL, van Gorp ECM, Hua KH.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Histological Findings in Testes of Baboons (Papio spp.) and Dwarf Bucks (Capra hircus) Subject to Repeated Immunisation Against GnRH. [PDF]

Vet Med Sci
Ferrín T, Martínez-Nevado E, García J, Toledano-Díaz A, Velázquez R, Alba E, Castaño C, Martinez-Madrid B, Santiago-Moreno J.   +8 more
europepmc   +1 more source

Comparative Immunohistochemical Study of Canine Mammary Tumours: Introducing of Triple-Negative Profile (ER^-/PR^-/HER2^-) in Benign Mammary Tumours of Animal Model. [PDF]

Vet Med Sci
Lak H, Amniattalab A.
europepmc   +1 more source

Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil-Ciprofloxacin Combination. [PDF]

Vet Med Sci
Soubai Z, Ziyate N, Rais R, Elhrech H, Aguerd O, Bouyahya A, Benali T, Akhazzane M, Mahir H, Fellahi S, Al Abdulmonem W, Houssni IE, Attarassi B, Auajjar N.   +13 more
europepmc   +1 more source

Occupational Hearing Loss in the Intensive Care Unit: A Comparative Study Between ICU and Non-ICU Nursing Staff. [PDF]

Nurs Crit Care
Song Z, Lee PJ, Bin L, Hampton T.
europepmc   +1 more source

Emergence of Goal-Directed Behaviors via Active Inference With Self-Prior. [PDF]

Dev Sci
Kim D, Kanazawa H, Yoshida N, Kuniyoshi Y.   +3 more
europepmc   +1 more source