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Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
The Lancet Child & Adolescent HealthBACKGROUND
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020.S. Faust, R. Haynes, Christine E. Jones, N. Staplin, E. Whittaker, T. Jaki, E. Juszczak, E. Spata, M. Wan, A. Bamford, P. Dimitri, A. Finn, J. Furness, A. Ramanan, C. Gale, K. Cathie, S. Drysdale, J. Bernatoniene, C. Murray, C. Roehr, P. Fleming, A. Riordan, S. Bandi, D. Jyothish, J. Evans, M. Emonts, Dominic Kelly, N. Pathan, P. Davies, Rosie Hague, L. Pollock, M. Semple, L. Peto, J. Baillie, Maya H. Buch, K. Jeffery, M. Knight, W. Lim, A. Montgomery, A. Mukherjee, A. Mumford, K. Rowan, G. Thwaites, M. Mafham, J. Emberson, Martin J. Landray, P. Horby, L. Chappell, J. Day, D. Dung, N. Quang, P. Binh, E. Burhan, B. Alisjahbana, J. Koirala, S. Basnet, E. Kestelyn, B. Basnyat, P. Gyanwali, R. Hamers, P. Sandercock, J. Darbyshire, D. Demets, R. Fowler, D. Lalloo, M. Munavvar, I. Roberts, A. Warris, J. Wittes, A. Craddock-Bamford, J. Barton, A. Basoglu, R. Brown, W. Brudlo, E. Denis, L. Fletcher, S. Howard, S. Musini, K. Taylor, G. Cui, B. Goodenough, A. King, M. Lay, D. Murray, W. Stevens, K. Wallendszus, R. Welsh, C. Crichton, J. Davies, R. Goldacre, C. Harper, F. Knight, M. Nunn, H. Salih, J. Welch, M. Campbell, G. Pessoa-Amorim, M. Zayed, J. Wiles, G. Bagley, S. Cameron, S. Chamberlain, B. Farrell, H. Freeman, A. Kennedy, A. Whitehouse, S. Wilkinson, C. Wood, C. Reith, K. Davies, H. Halls, L. Holland, R. Truell, K. Wilson, Emma Lingwood, L. Howie, M. Lunn, P. Rodgers, J. Amuasi, K. Baird, T. Bao, M. Bittaye, J. Bonney, U. D'Alessandro, M. Dhimal, T. Huyen, A. Jagne, A. Karkey, O. Maiga, E. Matey, B. Nadjm, J. Nel, S. Pant, K. Puspatriani, M. Rahardjani, S. Raijal, H. Rees, A. Rimainar, C. Roberts, A. Rocca, S. Shrestha, E. Usuf, C. Vidaillic, F. Wulandari, A. Alexander, M. Amezaga, C. Armah, A. Asghar, P. Aubrey, K. Barker-Williams, A. Barnard, J. Bartholomew, D. Beaumont-Jewell, S. Beddows, J. Beety, C. Birch, P. Boyle, M. Brend, M. Brookes, C. Callens, D. Campbell, H. Campbell, H. Cate, E. Chambers, K. Chapman, A. Coe, J. Collins, S. Crawshaw, S. Das, A. De Soyza, E. Denton, P. Dicks, M. Dolman, K. Donaldson, L. Dowden, S. Dowling, C. Drake, H. Duckles-Leech, H. Duffy, L. Gerdes, K. Gibbons, L. Gill, K. Gilmour, J. Goodwin, J. Graham, C. Green, C. Hall, A. Hall, K. Hampshire, J. Hanson, T. Harman, H. Harper, S. Harrison, J. Hicks, H. Hodgson, M. Hough, S. Jackson, G. Johnson, J. Kirk, N. Lemoine, C. Levett, S. Lock, T. Lockett, M. Logan, K. Lomme, J. Luo, N. McMillan, H. Membrey, N. Mguni, J. Minton, H. Monaghan, S. Murphy, N. Muzengi, M. Naz, I. Nickson, M. Odam, U. Ohia, E. Okell, A. Oliver, K. Pearson, K. Pine, R. Pleass, D. Porter, L. Porter, A. Potter, V. Poustie, S. Pratt, A. Price, A. Priest, A. Rodgers, C. Rook, P. Ryan, S. Sam, P. Sharratt, J. Sheffield, J. Shenton, K. Shirley, T. Skinner, H. Slade, M. Sutu, J. Taylor, E. Thomas, H. Tinkler, A. Unsworth, R. Usher, W. Van't Hoff, S. Walker, J. Walters, E. Walton, J. Warmington, E. Wayman, P. Williams, J. Williamson, D. Williamson, F. Yelnoorkar, M. Knight, K. Hodson, S. Pavord, C. Williamson, L. Bowman, F. Chen, R. Clarke, M. Goonasekara, W. Herrington, P. Judge, S. Ng, D. Preiss, E. Sammons, D. Zhu, C. Arkley, P. Bowker, J. Bruce, V. Byrne-Watts, G. Chapman, G. Coleman, T. Denwood, J. Gray, D. Harrison, N. Mather, H. Pinches, A. Rees, S. Rees, G. Turner, O. Abani, A. Abbas, F. Abbas, J. Abbas, K. Abbas, M. Abbas, S. Abbasi, H. Abbass, A. Abbott, N. Abdallah, A. Abdelaziz, M. Abdelfattah, B. Abdelqader, A. Abdul, B. Abdul, S. Abdul, A. Abdul Rasheed, A. Abdulakeem, R. Abdul-Kadir, A. Abdullah, A. Abdulmumeen, R. Abdul-Raheem, N. Abdulshukkoor, K. Abdusamad, Y. Abed El Khaleq, M. Abedalla, A. Abeer Ul Amna, L. Abel, K. Abernethy, M. Abeywickrema, C. Abhinaya, A. Aboaba, A. Aboagye-Odei, H. Aboelela, H. Abo-Leyah, K. Abouelela, A. Abou-Haggar, M. Abouibrahim, A. Abousamra, M. Abouzaid, M. Abraham, T. Abraham, A. Abraheem, J. Abrams, R. Abrams, H. Abu, A. Abu-Arafeh, S. Abubacker, A. Abung, Y. Abusamra, Y. Aceampong, A. Achara, D. Acharya, S. Acheampong, P. Acheampong, J. Acheson, S. Achieng, A. Acosta, R. Acquah, C. Acton, J. Adabie-Ankrah, P. Adair, F. Adam, M. Adam, H. Adamali, M. Adamczyk, C. Adams, D. Adams, K. Adams, L. Adams, N. Adams, R. Adams, T. Adams, L. Adamu-Ikeme, K. Adati, K. Adcock, A. Addo, O. Adeagbo, A. Adebiyi, O. Adedeji, Y. Adegeye, K. Adegoke, V. Adell, S. Adenwalla, F. Adeoye, O. Adesemoye, E. Adewunmi, A. Adeyanju, J. Adeyemi, T. Adeyemo, R. Adhikary, A. Aditya, G. Adkins, A. Adnan, J. Aeron-Thomas, D. Affleck, C. Afnan, M. Afridi, Z. Aftab, M. Agarwal, R. Agbeko, C. Agbo, S. Aggarwal, A. Aghababaie, L. Aguilar Jimenez, S. Ahamed Sadiq, M. Ahammed Nazeer, A. Ahmed, B. Ahmed, F. Ahmed, H. Ahmed, I. Ahmed, K. Ahmed, L. Ahmed, M. Ahmad, N. Ahmed, O. Ahmed, R. Ahmed, S. Ahmad, S. Ahmed, R. Ahmed Ali, B. Ahmed Mohamud, S. Ahmer, A. Ahonia, C. Aiken, D. Ail, M. Ainsworth, M. Aissa, L. Aitken, B. Ajay, A. Ajibode, A. Ajmi, N. Akhtar, S. Akili, B. Akinbiyi, O. Akindolie, Y. Akinfenwa, O. Akinkugbe, I. Akinpelu, M. Akram, O. Aktinade, U. Akudi, A. Al Aaraj, A. Al Balushi, M. Al Dakhola, A. Al Swaifi, E. Al-Abadi, A. Alabi, N. Aladangady, M. Alafifi, A. Alam, S. Alam, A. Al-Asadi, K. Alatzoglou, P. Albert, L. Albon, A. Alcalá, G. Alcorn, S. Alcorn, A. Aldana, D. Alderdice, A. Aldesouki, R. Aldouri, J. Aldridge, N. Aldridge, A. Alegria, C. Alexander, J. Alexander, P. Alexander, J. Al-fori, L. Alghazawi, O. Alhabsha, B. Al-Hakim, R. Alhameed, M. Al-Hayali, S. Al-Hity, A. Ali, F. Ali, J. Ali, M. Ali, N. Ali, O. Ali, R. Ali, S. Ali, E. Aliberti, J. Alin, A. Alina, A. Alipustain, F. Aliyuda, K. Alizaedeh, M. Al-Jibury, S. Al-Juboori, M. Al-Khalil, A. Alkhudhayri, M. Alkhusheh, F. Allan, N. Allan, A. Allanson, R. Allcock, E. Allen, J. Allen, K. Allen, L. Allen, P. Allen, R. Allen, S. Allen, T. Allen, A. Alli, K. Allison, B. Allman, D. Allsup, H. Allsop, L. Allsop, A. Almahroos, H. Al-Moasseb, M. Al-Obaidi, L. Alomari +499 moresemanticscholar +1 more sourceSome of the next articles are maybe not open access.Related searches:
Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol
The Lancet OncologySummary Background Metformin is a widely used anti-diabetic drug. Several studies have suggested that metformin has anticancer activity in some malignancies, including prostate cancer.S. Gillessen, Laura Murphy, Nicholas D. James, Ashwin Sachdeva, O. El-Taji, H. Abdel-Aty, A. Adler, C. Amos, Gerhardt Attard, M. Varughese, J. Gale, Simon Brown, N. Srihari, A. Birtle, Michael Brown, K. Chan, Simon Chowdhury, W. Cross, D. Dearnaley, Omar Din, P. Dutey-Magni, D. Gilbert, C. Gilson, Struan Gray, E. Grist, U. Hofmann, Andrew Hudson, Y. Jain, G. Jeyasangar, Rob J. Jones, M. Kayani, R. Langley, Zafar Malik, M. Mason, D. Matheson, C. McAlpine, A. Macnair, R. Millman, Claire Murphy, M. Padden-Modi, O. Parikh, Chris C Parker, H. Rush, M. Russell, R. Srinivasan, S. Sundar, Jacob S Tanguay, F. Turco, Patrick Williams, M. Sydes, Mahesh K. B. Parmar, Louise C. Brown, Noel W. Clarke, Gerhardt Simon Noel William David Silke Nicholas Rob Zafar Attard Chowdhury Clarke Cross Dearnaley Gillessen , Gerhardt Attard, Simon Chowdhury, Noel W. Clarke, W. Cross, D. Dearnaley, S. Gillessen, Nicholas D. James, Rob J. Jones, Zafar Malik, Chris C Parker, J. Russell, D. Aebersold, John Anderson, Johann S de Bono, M. Mason, J. Masters, Rick Popert, Alastair WS Ritchie, G. Thalmann, D. Matheson, R. Millman, Patrick Williams, J. Dwyer, David Hoe-Richardson, J. Stansfeld, C. Amos, K. Chan, Claire Murphy, Louise C. Brown, D. Gilbert, R. Langley, Mahesh K. B. Parmar, M. Sydes, N. Atako, Cheryl A Pugh, H. Abdel-Aty, M. Padden-Modi, M. Kayani, Sarah Howlett, H. Rush, C. Gilson, A. Macnair, R. Emsley, Bertrand F. Tombal, R. de Wit, Christopher Williams, John R. Yarnold, Doug Altman, R. Hall, Paula Ghaneh, Tim Clayton, Jan-Erik Dember, P. Nash, J. Larkin, J. Ledermann, John Fitzpatrick, A. Horwich, D. Kirk, J. Paul, P. Dutey-Magni, Laura Murphy, M. Nankivell, Sophie Barthel, A. Cook, D. Bratton, C. Brawley, B. Choodari-Oskooei, Trinh H K Duong, A. Embleton, M. Gannon, F. Ingleby, E. James, R. Jinks, G. Jovic, Patrick Royston, M. Spears, C. Carvalho, Mazna Anjun, A. Griffiths, F. Hudson, P. Maniatis, C. McAlpine, Clare Shakeshaft, Horeja Njai, Shabinah S. Ali, Sofeya Ishqa, D. Noor, M. Richmond, Kay Sanders, L. Clarke, M. Buckner, A. Brown, J. Calvert, Rahela Choudhury, Zoe Cotton, A. Cursley, Tom Fairfield, S. Forcat, Michelle Gabriel, Charlene Green, A. Gregory, Anna A. Herasimtschuk, C. Hogan, Brooke Jackson, Sarah Jackson, Neil Kelk, James Latham, Dymphna Lee, Sarah E Miller, Sharon Naylor, J. Nuttall, Jennifer Petrie, Orla Prendiville, F. Schiavone, Clare Shakeshaft, Aminata Sy, C. Tyson, Hannah G. Vaughan, Chris Wanstall, Katie Ward, M. Weiss, Arlen Wilcox, A. Macnair, Sarah K Meredith, C. Chung, C. Diaz-Montana, G. Marley, Lindsey Masters, M. Rauchenberger, Stephen Townsend, Nadine Van-Looy, Carly Au, Will Cragg, Dominic Hague, Zaheer Islam, Sajad Khan, D. Mounsey, N. Tappenden, Shaan Akbar, Yumna Ali, Ify Ejizu-Allen, D. Clarke, D. Dobson, Abinaya Baskaran, Isabella Jaques, Alexander Lawton, M. Hook, Nazia Parkar, Eva Ades, Katherine Beaney, Nargis Begum, Katharine Bellenger, Lina Bergstrom, Veronica Birzu, Robin Carpenter, E. Clark, E. Donoghue, Amy Fiddament, Shree Gajjar, H. Gardner, Jenna Grabey, Richard Gracie, S. Hassan, Jordan P Hedges, Robyn Henry-Cockles, W. Hudson, Sofeya Ishaq, Danielle Johnson, S. Khan, Zohrah Khan, L. Ly, Adele Mabley, Georgia Mannion-Krase, Jacque Millett, M. Nicholas, Rachel Ogunleye, Meghna Pandya, Reena Patel, S. Peres, T. Philips, P. Pollock, C. Rajapakse, T. Smith, Hannah Sweeney, A. Upadhyaya, L. Van Dyck, P. Vaughan, Stephanie Wetton, Andrew Whitney, S. Yurdakul, Nicola Joffe, M. Murray, T. Fisher, Lynda Micklewright, E. Adesanya, A. Amin, H. Babiker, Bryony Bathie, H. Chapman, Georgia Cowley, L. Dobson, James P. Dunn, R. Dunn, Ben Forson, Nasir Jamil, Tasheeka Jeyapalan, S.H. Kang, Harry Kitson, R. Lo, Joseph Martin, N. Merzouki, R. Phillips, Jamie Simmons, Sh. Sohail, Jeevan Sohal, C. The, Nat Thorogood, Stephanie Tsenti, Alexandra Wadia, Stephanie Wetton, S. Burdett, David Fisher, P. Godolphin, Larysa E Rydzewska, J. Tierney, C. Vale, Sarah Banbury, Lesley Brempong, E. Harding, Gill Hurst, Nishat Tasnim, Jemima Thompson, Estelle Cassolly, Pierre Fustier, Eloïse Kremer, Corinne Schar, Adnan Ali, Radhi Anand, Hassan Douis, Dan Berney, Michael Brown, R. Eeles, O. El-Taji, S. Friedrich, E. Grist, Anis A. Hamid, Á. Haran, Craig Jones, A. Hassan, A. Hoyle, S. Kudahetti, S. Lall, Gianmarco Leone, Hing Leung, S. Lise, L. Mendes, Karolina Nowakowska-Pawelkowicz, C. Parker, Marina A. Parry, A. Parry-Jones, Ashwin Sachdeva, C. Sweeney, S. Thakali, Nina Tinariu, M. Vico, S. Santos Vidal, D. Wetterskog, A. Wingate, Carla Bautista, Paolo Cremaschi, T. Hambrock, A. Landless, Nik Matthews, Mariana Buongermino Pereira, Kamila Sychowska, D. Waugh, L. Zakka, Christian Smith, Christine Kotonya, Elin Jones, H. Tench, Mark Narain, P. Jones, R. Canavan, Sajid Durrani, E. Nurse, Gwenan Parry Jones, Kirsty Marie Dennett, Rhian Elin Jones, Sandra Griffiths nee Evens, C. Morgan, K. Williams, Llinos Strange, S. Thomas, Toby Frederick Trugeion-Smith, Basharat Jameel, Bleddyn Edwards, Geraint H. Morgan, J. Edwards, D. Robson, H. McGuinness, R. Loosley, C. Duggan, S. Jones, Abigail Hynes, R. Wolf-Roberts, Albert Edwards, Charlotte Mott, Ifigenia Vasiliadou, Lavarniya Rajakumar, M. Sridharan, P. Brulinski, R. Raman, R. Malde, Stephane Tankoua, Arafat Mizra, Carys Thomas, Clary Evans, Kannon Nathan, Kathryn Lees, M. Cominos, M. Fenton, Mohammed Osman, N. Mithal, S. Beesley, Sugeeta Sukumar, U. Panwar, Coral Greenstreet, H. Blackgrove, Katy Taylor, V. Williamson, Natalie Catt, Arafat Mirza, S. Gibson, Steve Dann, A. Gillian, Miguel Capo-Mir, Cindy Slater, Hasmath Marjolin, N. Crisp, Rachel Larkins, Sandra Holness, S. Lines, Susan Rogers, T. Hammond, C. White, J. Buckley, Laura Kehoe, Lesley Rose, L. Gladwell, Sarah Lightfoot, Tracy Boakes, Alba Tubau, Bonny Appleby, Lynette Wray, Louise Allen, Marian Wood, A. Sanni, C. Pelham, Elizabeth A. Williamson, Hilary Zurakovsky, J. Baker, Joanne Williams, J. Davies, Karen Robinson, Kathleen (Kathy) Walsh, K. Mears, Kim Z Travis, Margaret Lipsham, Paula Whichelo, Sharon Middleton, S. Kelly, S. Drakeley, S. Loveland, M. Young, Denise Crawford, A. Sabharwal, Andy Theobold, J. Carpenter, K. Hyde, T. Pwint, Christopher Alcock, Gerard Andrade, Joanne Brady, N. Panakis, P. Camilleri, P. Chakraborti, Sean M. O'Cathail, J. Greenland, M. Mathew, R. Kurup, Neil Trew-Smith, A. Ngumo, Gail Varley, J. Weir, Manisha Joshi, S. Gettings, C. Padilla-Harris, M. Aldersley, Margaret Bowerbank, M. Taylor-Siddons, Tracey Stammers, A. Osadcow, K. Herbert, R. Mancinelli, Sarah Manyangadze, Christina Collins, Hazel Wynn, Iram Husain, J. Bains, Roisin Kavanagh, A. Protheroe, A. Tufail, D. McIntosh, Helena Belikova, J. Ansari, Rebecca Muirhead, Xia Ren, Christina Lai, E. Khan, Hilary Glen, Lye Mun Tho, Nicholas Macleod, R. Mahmood, Stefan Nowich, K. O'Hara, Kristy Ross, B. McGlynn, Mark Wilson, Philip Cannon, Kathleen Smith, D. Dunn, J. Mcclements, S. Walton, A. Murphy, D. Gilmour, E. Watson, Lillian White, L. McNeil, Margaret McKernan, Sharon Meehan, Clare Love, Claudia Coubrough (Turley), Danna Yorston, Diane Woodburn, D. Hunter +499 moresemanticscholar +1 more sourceAn International Multicenter Cohort Study on Implantable Cardioverter Defibrillators for the Treatment of Symptomatic Children with Catecholaminergic Polymorphic Ventricular Tachycardia.
Heart RhythmBACKGROUND
Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter defibrillators (ICDs) are commonly advised.Avani Lamba, T. Roston, P. Peltenburg, D. Kallas, S. Franciosi, K. Lieve, Prince J. Kannankeril, Minoru Horie, S. Ohno, Ramon Brugada, T. Aiba, Peter S Fischbach, Linda M. Knight, J. Till, S. Kwok, V. Probst, D. Backhoff, M. LaPage, Anjan S Batra, F. Drago, K. Haugaa, Andrew D. Krahn, T. Robyns, H. Swan, T. Tavacova, Joseph Atallah, M. Borggrefe, B. Rudic, G. Sarquella-Brugada, E. Chorin, Allison C. Hill, J. Kammeraad, Anna Kamp, Ian Law, James Perry, Jason D. Roberts, Svjetlana Tisma-Dupanovic, C. Semsarian, Jonathan R. Skinner, J. Tfelt-Hansen, I. Denjoy, A. Leenhardt, P. Schwartz, Michael J. Ackerman, Arthur A. Wilde, C. van der Werf, S. Sanatani +46 moresemanticscholar +1 more sourceOrganisation of mental health care for adults in Belgium
, 2019 SCIENTIFIC REPORT 29 -- CHAPTER 00 OUTLINE OF THE STUDY 29 -- 1 BACKGROUND 29 -- 2 RESEARCH OBJECTIVE 30 -- 3 OUTLINE OF THE STUDY 31 -- 4 LIMITATION/SCOPE OF THE STUDY 31 -- 5 REFERENCES 32 -- CHAPTER 01 DESCRIPTION OF THE BELGIAN MENTAL HEALTH CARE ...Patriek Mistiaen, Justien Cornelis, Jens Detollenaere, Stephan Devriese, María-Isabel Farfan-Portet, C. Ricour +5 moresemanticscholar +1 more source
