Results 131 to 140 of about 448,797 (199)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of the Cultivation Methods of Students’ Engineering Thinking Ability in the Teaching of Materials for Mechanical Engineering

, 2020
Jing Zou, Jiayin Zou, Caihong Zhang, Kai Zheng   +3 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Surface reinforcement of rice straw fibers for epoxy composites by ultrasonic, plasma, and sodium carbonate-assisted hybrid treatments. [PDF]

RSC Adv
Harianingsih, Palanisamy S, Fitriyana DF, Siregar JP, Qudus N, Alfarraj SA, Alharbi SA, Abbas M, Kalathil S, Belay M.   +9 more
europepmc   +1 more source

Characterization of the consequences of the fungal activity on the mechanical properties of a woody stem in structures of ecological engineering of protection against the natural hazard

, 2017
Jean-Baptiste Barré
openalex   +1 more source

Assessing the Efficacy of Online Lecture Modules in a Core Mechanical Engineering Undergraduate Course

, 2017
Mohammed S. Taboun, Robert W. Brennan
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correction: The effect of protic ionic liquid in the reduction of air contaminant gases emitted from electrical discharge machining in the presence of magnetic field. [PDF]

Sci Rep
Karamzadeh B, Shabgard M, Gholipoor A, Shekaari H, Golmohammadi B.   +4 more
europepmc   +1 more source

Make it tangible: Laser cutter models in first-year mechanical engineering education

, 2018
Quentin Lohmeyer, Mirko Meboldt
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source