Results 71 to 80 of about 448,797 (199)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development of experimental complex for formation of professional competence of "Mechanical engineering" specialists

, 2015
V.N. Statsenko, Maya Bernavskaya
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Engineering Robust yet Dissociable Phase-Separated Nanodomains to Yield Mechanically Robust Elastomers and Elastic Fibers for Cryogenic Applications

Xiaohan Wang, Yidi Zhuang, Yuqin Wang, Jing Kang, Lin Ma   +4 more
openalex   +1 more source

Special issue on environmentally conscious technologies in mechanical engineering

, 2015
Jongwon Seok, Sridhar Idaparapati, Hyung Wook Park, Hae‐Jin Choi, Ramesh Singh, Martin Byung‐Guk Jun   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Correction: Comparative study of advanced hydrogen liquefaction using triple cascade mixed refrigerant cycles with integrated energy exergy economic and environmental analysis. [PDF]

Sci Rep
Ismail MS, ElSeuofy MAE, Attia AE, El-Maghlany WM, ElHelw M.   +4 more
europepmc   +1 more source

Ion exchange engineering of 2D mica for tunable mechanical and dielectric properties

Xinchen Gao, ZHENBIN GONG, Yuqian Huang, Jie Tao, Youzhuan Zhu, Junyan Zhang   +5 more
openalex   +1 more source

Causal Impressions of Japan in the Eyes of a British Mechanical Engineering Researcher

, 1976
Bradley Dodd, Hideaki Kudo
openalex   +2 more sources