Results 1 to 10 of about 1,008 (88)

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Direct estimation of activity concentration in regional voxels with application to 177Lu peptide receptor radionuclide therapy

Medical Physics, Volume 53, Issue 4, April 2026.
Abstract Background Quantitative SPECT in radionuclide‐therapy is limited by partial‐volume effects (PVEs). The implementation of regional voxels (r.v.), estimating mean activity concentrations in regions directly from projections, offers a promising alternative for the geometry‐specification to reduce PVEs.
Johan Gustafsson, Erik Larsson, Katarina Sjögreen Gleisner   +2 more
wiley   +1 more source

Cutting‐edge advances in bicyclic peptide‐based radiotracers for cancer imaging and theranostics

VIEW, Volume 7, Issue 2, April 2026.
Bicyclic peptides, a burgeoning subset of bicyclic macrocycles, are characterized by two loops stabilized through three linkages of the central chemical scaffolds. As an immense potential platform for radiotracers development, bicyclic peptide‐based radiotracers have yielded encouraging results in preclinical and clinical trial studies.
Hengyi Ou, Xiaobo Wang, Fei Kang
wiley   +1 more source

The effect of LysaKare infusion on serum potassium levels in patients with gastroenteropancreatic neuroendocrine tumours eligible for treatment with [177Lu]Lu‐DOTA‐TATE: A post‐authorisation safety study

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract A post‐authorisation safety study (PASS) was conducted to assess the impact of LysaKare (2.5% Lysine‐Arginine solution) on serum potassium concentrations and its safety/tolerability profile in patients with gastroenteropancreatic neuroendocrine tumours (GEP‐NET) eligible for 177Lu‐DOTATATE treatment.
Johannes Hofland, Chiara Maria Grana, Martin O. Weickert, Andrew R. Moore, Tahir Shah, Vineet Prakash, Agnieszka Kolasińska‐Ćwikła, Wouter W. de Herder, Francesca Spada, Lingfei Xu, Ramon Fite, Yuan Wu, Jarosław B. Ćwikła   +12 more
wiley   +1 more source

Gold Nanoparticles Loaded With Lutetium‐177 Labeled DOTA‐TATE Exhibit Superior AR42J Cell Affinity and Extended Blood Circulation in AR42J Tumor Xenografts

Nano Select, Volume 7, Issue 2, February 2026.
The present study reports the development of a gold nanoparticle‐based delivery system functionalized with the established radiopharmaceutical [177Lu]Lu‐DOTA‐TATE. This design aims to enhance tumor‐targeting efficacy and improve the overall in vivo pharmacokinetic profile. In vitro studies demonstrated enhanced specificity toward somatostatin receptor (
Dheeraj Kumar, Rani Gnanasekar, Sheela Muralidharan, Shubhangi Mirapurkar, Krishna Mohan Repaka, Anupam Mathur, Madhava B. Mallia   +6 more
wiley   +1 more source

Accuracy and precision of few‐time‐points renal dosimetry for [177Lu]Lu‐PSMA‐617 therapy: Analysis with nonlinear mixed‐effects modeling

Medical Physics, Volume 53, Issue 1, January 2026.
Abstract Background Determination of time‐integrated activity (TIA) with a reduced number of imaging sessions is essential for minimizing patient burden and clinical workload in the dosimetry of [177Lu]Lu‐PSMA‐617. One approach to achieve this is by performing single‐time‐point (STP) dosimetry.
Assyifa R. Hakim, Deni Hardiansyah, Elham Yousefzadeh‐Nowshahr, Ursula Nemer, Rien Ritawidya, Felix Kind, Ambros J. Beer, Philipp T. Meyer, Gerhard Glatting, Michael Mix   +9 more
wiley   +1 more source

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

Cancer Communications, Volume 45, Issue 11, Page 1431-1455, November 2025.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li, Xuejun Wen, Rebeka Rita Reszegi, Hemavarshini Kamalrhaj, Wolfgang J. Parak, Xiaoyuan Chen, Jingjing Zhang   +6 more
wiley   +1 more source

Glucagonoma and Glucagonoma Syndrome: An Updated Review

Clinical Endocrinology, Volume 103, Issue 4, Page 417-426, October 2025.
ABSTRACT Background Glucagonoma is a rare well‐differentiated slowly proliferating pancreatic neuroendocrine tumour, characterized by several manifestations including necrolytic migratory erythema, weight loss, diabetes and anaemia. Aim The purpose of the current review was to acknowledge literature about this rare tumour discerning the clinical ...
Sofia Anelli, Rossella Mazzilli, Virginia Zamponi, Beatrice Giorgini, Bianca Golisano, Camilla Mancini, Flaminia Russo, Francesco Panzuto, Antongiulio Faggiano   +8 more
wiley   +1 more source

Peptide‐Drug Conjugates: A New Hope for Cancer

Journal of Peptide Science, Volume 31, Issue 8, August 2025.
Peptide‐drug conjugates (PDCs) are emerging cancer therapeutics inspired by antibody‐drug conjugates, offering targeted delivery via peptide ligands. Despite structural versatility, challenges like instability and rapid clearance hinder clinical progress.
Amy Armstrong, Fleur Coburn, Yanyamba Nsereko, Othman Al Musaimi   +3 more
wiley   +1 more source