Results 111 to 120 of about 44,506 (169)

Urban-rural disparities in the trends and causes of maternal deaths in Jinan, 1991-2025: a longitudinal trend analysis. [PDF]

Front Public Health
Zheng X, Pan J, Sun Q, Tan Y, Ma X, Li Z.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Prostate MRI Quality Assessment: PI-QUAL and Factors Influencing Image Quality. [PDF]

J Korean Soc Radiol
Song JS, Jang W.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Automatic segmentation and PI-RADS grading of prostate cancer for biparametric MRI. [PDF]

Front Med (Lausanne)
Li Y, Huang M, Wu Y, Zhang Y.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Protocol for the SACLA trial: Efficacy and safety of subretinal monteplase for submacular hemorrhage in a phase II single-arm multicenter decentralized clinical trial. [PDF]

PLoS One
Yoshida N, Kobayakawa Y, Funakoshi K, Kimura S, Hosoya K, Shinkawa Y, Furukawa T, Mitsutake T, Hoshiko T, Takamori A, Kawahara N, Terasaki H, Oishi A, Koizumi H, Inoue T, Takeda A, Ikeda Y, Yoshida S, Morizane Y, Kadonosono K, Inoue M, Kamei M, Todaka K, Sonoda KH, Enaida H.   +24 more
europepmc   +1 more source