Results 61 to 70 of about 25,940,484 (219)
, 1909 A document from an extensive collection spanning four generations of the Woodward family that operated merchant pig iron companies in West Virginia and Alabama. The collection begins with Stimpson Harvey Woodward (S. H.
Durkee, H. R. (Henry R.)
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, 2005 Reaction of LA1 (1) or [LA1{eta'-C-2(SiMe3)(2)}] (2) (L = HC[(CMe)-(NAr)](2), Ar = 2,6-iPr(2)C(6)H(3)) with azobenzene affords a five-membered ring compound [LA1{N(H)-o-C6H4N(Ph))}] (3).
朱红平 +7 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Oliver H. P. Scott Civil War letter
This collection contains a letter written by Maj. Oliver H. P. Scott, commanding the 3rd Iowa Cavalry at Helena, Ark., to Maj. John W.
Scott, Oliver H. P., 1815-1880
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
[Report to W. P. Gannaway by H. M. Hart, December 3, 1963 #1]
, 1963 Intelligence report addressed to Captain W. P. Gannaway of the Dallas Police Department. The report, which was submitted by H. M.
Dallas (Tex.). Police Department.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
[Report to W. P. Gannaway by M. H. Brumley, January 27, 1964 #2]
, 1963 Photocopy of a report addressed to Captain W. P. Gannaway of the Dallas Police Department. The report, which was submitted by M. H.
Dallas (Tex.). Police Department.
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source