Results 31 to 40 of about 14,899,830 (217)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Analysis of direct segregated boundary-domain integral equations for variable-coefficient mixed bvps in exterior domains [PDF]

open access: yes, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2013 World Scientific Publishing.Direct segregated systems of boundary-domain integral equations are formulated for the mixed (
Mikhailov, SE   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Integral Representation of a Series Which One Includes the Mathieu A-Series

open access: yes, 2004
Integral expression is deduced for the series S(r,μ,ν,a)=∑n=1∞2F1ν−μ+12,ν−μ2+1;ν+1;−r2a(n)2a(n)ν−μ+1(a(n)2+r2)μ−1/2, where r>0, μ>1/2, ν ...
Pogány, Tibor K
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Fourier integral and J. G. Mikusiński's distributions

open access: yes, 1966
summary:In diesem Artikel werden die wichtigsten Begriffe aus der Algebra und Analysis der Distributionen von J. G. Mikusiński behandelt. Im Rahmen dieser Distributionstheorie wird unter anderem über die Darstellung von Funktionen durch das Fouriersche ...
Matušů, Josef
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

J-integral as a useful fracture parameter for analysis of desiccation cracking in clayey soils

open access: yes, 2013
J-integral as a useful fracture parameter for analysis of desiccation cracking in clayey ...
Susanga Costa (13096575)   +2 more
core   +1 more source

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