Results 141 to 150 of about 13,841,046 (208)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Computational Fluid Dynamics as an Adjunctive Functional Assessment of Airway Narrowing After Pulmonary Artery Banding: A Case Report. [PDF]

Respirol Case Rep
Saijo S, Noda M, Arai Y, Moriwaki K, Miyoshi K, Terazawa M, Otani S, Momota K, Sato H, Takashima T, Nunomura T, Ishihara M, Itagaki T, Iwasaki T, Oto J.   +14 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

MAXTIA: A high-throughput platform for rapid functional epitope mapping by kinetic screening of mutant libraries. [PDF]

Protein Sci
Kim K, Matsunaga R, Yokoo T, Nakakido M, Tsumoto K.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Remote Spectral Detection of Canopy Functional Dimensions Varying Within and Across Forest Types. [PDF]

Ecol Lett
Wu F, Liu S, Zohner CM, Townsend PA, Crowther TW, Peñuelas J, Yang D, Yang N, Dong T, Xu W, Wang Z, Liu X, Dai G, Dong J, Durán SM, Schneider FD, Zeng Y, Cornelissen JHC, Kattge J, Wu J, Asner GP, Cavender-Bares J, Reich PB, Yan Z.   +23 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Physical activity, sex differences, and functional exercise capacity in bronchiectasis: Insights from a South Asian cohort. [PDF]

PLoS One
Bhat A, Lee AL, Maiya GA, Manu MK, Mohapatra AK, Magazine R, Vaishali K.   +6 more
europepmc   +1 more source