Results 171 to 180 of about 13,841,046 (208)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Radial Distribution Function in a Two-Dimensional Core-Shoulder Particle System. [PDF]

J Phys Chem B
Wassermair M, Kahl G, Archer AJ, Roth R.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

PUFFIN: protein unit discovery with functional supervision. [PDF]

Bioinformatics
Uludoğan G, Giledereli B, Ozkirimli E, Özgür A.   +3 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Functional Outcomes of Total Hip Replacement in Inflammatory Hip Arthritis: Influence of Disease-Modifying Anti-Rheumatic Drugs and Postoperative Analgesic Management. [PDF]

J Pharm Bioallied Sci
Ganesh Kumar S, Balaji Subramaniam K, Pajani S, Arul Vignesh K, Periasamy P.   +4 more
europepmc   +1 more source

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A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks. [PDF]

Nat Commun
Shain C, Fedorenko E.
europepmc   +1 more source

Vascularized Anterior Interosseous Nerve Transfer: A Novel Concept to Treat Ulnar Nerve Injury. [PDF]

Plast Reconstr Surg Glob Open
Milek D, J Choi M, Munkwitz S, Fullerton N, K Tadisina K.   +4 more
europepmc   +1 more source