Results 61 to 70 of about 13,841,046 (208)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
, 2008 Several types of K+ channels have been identified in epithelial cells. Among them high conductance Ca2+- activated K+ channels (BK channels) are of relevant importance for their involvement in regulatory volume decrease (RVD) response following ...
MAFFIA, Michele +10 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
K-centres functional clustering of multivariate functional data
, 2016 碩士近年來函數型資料分析逐漸受到重視，而函數型資料之分群分析在實務應用上更是重要的議題。本研究主要是想探討多變量函數型資料的分群問題，當樣本中的每個觀察對象均具有多個變量的函數型資料時，如何找到所有觀測對象的合理分群結構是個尚待解決的問題。本研究將提出一套新的 K 中心多變量函數型分群演算法，其根據 Chiou 與 Li (2007) 對單變量函數型資料所提出的 K 中心函數型分群之概念，利用變量本身的變異程度與不同變量間的相關性來決定各變量適當的權數，並以各變量之加權距離來做分群 ...
郭令証;Kuo, Ling-Cheng
core
2020 Virtual K-State First Celebration
, 2021 In a virtual celebration, K-State First presents the winners for the 2020 First-Year Student Advocate and K-State First Book awards. The 2020 First-Year Advocate Award winners: Faculty/staff recipient - Jessica Henault Student recipient - Julia ...
K-State First
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source