Results 51 to 60 of about 7,921,324 (219)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Continuous functions on products of compact Hausdorff spaces
, 2000 We investigated the spaces of continuous functions on countable products of compact Hausdorff spaces. Our main object here is to extend the discussion to arbitrary products of compact Hausdorff spaces.
Namioka, I, Jayne, JE, Rogers, CA
core
Some Fixed Point Theorems in Fuzzy n-Normed Spaces [PDF]
, 2010 The main purpose of this paper is to study the existence of a fixed points in fuzzy n-normed spaces. we proved our main results, a fixed point theorem for a self mapping and a common fixed point theorem for a pair of weakly compatible mappings on fuzzy n-
Rahmat, Mohamad Rafi Segi +1 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Diametric theorems in sequence spaces
, 1992 Ahlswede R, Cai N, Zhang Z. Diametric theorems in sequence spaces. Combinatorica. 1992;12(1):1-17.We determine in almost all Manhattan lattices configurations, which for specified diameter have maximal cardinality.
Cai, Ning, Zhang, Zhen, Ahlswede, Rudolf
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Non-k-equal configuration and immersion spaces [PDF]
Doctor of PhilosophyDepartment of MathematicsVictor TurchinWe say the configuration space is the space of configurations of n distinct, labeled points in R d . We can imposea non-k-equal condition on the configurations that no k points coincide.
Grossnickle, Keely
core
, 2005 As is well known, k-spaces are characterized as quotient spaces of locally compact spaces. For a certain k-space X, we give characterizations on X for X×Y to be a k-space for every space Y in some class of k-spaces.
Tanaka, Yoshio
core +1 more source