Disulfidptosis modification patterns are involved in the immune microenvironment regulation of septic acute respiratory distress syndrome. [PDF]
Braz J Med Biol ResZhang Q, Ge J.
europepmc +1 more source
The life expectancy gains from pharmaceutical drugs: a critical appraisal of the literature [PDF]
Several studies suggest that, on the basis of life expectancy (LE) regressions, new pharmaceutical drugs are responsible for some of the marked gains in LE observed over the last 50 years. We critically appraise these studies.
Emmanuelle Piérard +2 more
core
Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids
Advanced Science, EarlyView.Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang +12 more
wiley +1 more source
Causal Implication of CD52-Driven Immune Dysregulation in Sarcopenic Obesity: Integrating Mendelian Randomization and Multiomics Profiling. [PDF]
Clin Interv AgingXuekelati S +7 more
europepmc +1 more source
Patterns of Retirement as Reflected in Income Tax Records for Older Workers [PDF]
If retirement means a substantial and sustained reduction in the time spent working for pay or profit, measurement requires a definition of substantial and sufficient observations of the same individuals to determine whether a transition from “working ...
Byron G. Spencer +2 more
core
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Integrating multi-omics analysis identifies DNA damage-related gene CLSPN as a biomarker in gastric cancer. [PDF]
Sci RepMa Q +5 more
europepmc +1 more source
Measurement Errors in Recall Food Expenditure Data [PDF]
Household expenditure data is an important input into the study of consumption and savings behaviour and of living standards and inequality. Because it is collected in many surveys, food expenditure data has formed the basis of much work in these areas ...
Matthew Brzozowski +2 more
core
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery. [PDF]
EpilepsiaMatouskova B +9 more
europepmc +1 more source