Results 181 to 190 of about 2,393,421 (215)

Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma. [PDF]

Pharmgenomics Pers Med
Li S, Zhang C, Lv S, Zhang Z, Xu D, Xu T.   +5 more
europepmc   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Multiomics Integration Analysis Reveals the Regulatory Mechanisms of Efferocytosis in Diabetic Kidney Disease. [PDF]

Inflammation
Kang Y, Jin Q, Zhou M, Zheng H, Li A, Li D, Wang X, Zhou J, Lv J, Wang Y.   +9 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Analysis of microarray and single-cell RNA-seq finds gene co-expression, cell-cell communication, and tumor environment associated with cytoskeleton protein in epithelial-mesenchymal transition in ovarian cancer. [PDF]

Discov Oncol
Abroudi AS, Jalaeianbanayan A, Djamali M, Azizi H.   +3 more
europepmc   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

ST-Elevation Myocardial Infarction Systems of Care in Africa: A Scoping Review. [PDF]

Glob Heart
Pool AJ, Smit PC, Slabber H, Stassen W.
europepmc   +1 more source

Designing Scalable Mechano‐Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation

Advanced Science, EarlyView.
Can a surface be designed to physically break viruses? This study explores how nanoscale geometry—specifically the spacing of tiny pillars—can determine whether viruses remain intact or rupture. Using flexible acrylic and a scalable fabrication process, the authors develop nanopillared, transparent surfaces that show strong antiviral activity without ...
Samson W. L. Mah, Denver P. Linklater, Vassil Tzanov, Chaitali Dekiwadia, Sergey Rubanov, Phuc H. Le, Laleh Tafakori, Ranya Simons, Graeme Moad, Soichiro Saita, Takashi Yanagishita, Hideki Masuda, Vladimir Baulin, Natalie A. Borg, Elena P. Ivanova   +14 more
wiley   +1 more source

Carbohydrate fatty acid monosulphate ester adjuvant enhances the immunogenicity of influenza antigens <i>via</i> TLR4/2-dependent mechanisms. [PDF]

Front Immunol
Retnakumar SV, Singh SC, Bonam SR, Chauvin C, Mathew MJ, Nielsen IB, Boyle C, Hilgers L, Søgaard M, Platenburg PP, Bayry J.   +10 more
europepmc   +1 more source

Multi-Model Ensembles in Infectious Disease and Public Health: Methods, Interpretation, and Implementation in R. [PDF]

Stat Med
Shandross L, Howerton E, Contamin L, Hochheiser H, Krystalli A, Consortium of Infectious Disease Modeling Hubs, Reich NG, Ray EL.   +7 more
europepmc   +1 more source