Results 131 to 140 of about 399,246 (222)

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Development of machine learning predictive models for estimating pharmaceutical solubility in supercritical CO₂: case study on lornoxicam solubility. [PDF]

Front Chem
Chao L, Wang Y, Erta B, Guo W, Wang H, Zhao C, Yang Y.   +6 more
europepmc   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Educational performance of TikTok short videos for age related macular degeneration and its link to user engagement. [PDF]

Front Med (Lausanne)
Jiang L, Jiang X, Shi X, Hu X, Song C, Yang W, Tong Y.   +6 more
europepmc   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Association between prealbumin levels and the risk of osteoporosis among individuals aged 50 and above in Southwest China: a retrospective case-control study. [PDF]

Front Med (Lausanne)
Zhao X, Cai C, Tang C, Zhang Z, Huang X, Chu T.   +5 more
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

BMI and its association with patient-reported outcome measures following revision hip surgery. [PDF]

Bone Jt Open
Baumber R, Mehmood A, McCulloch R, Pereira SMP, Warwick E, Hart A, Moonesinghe SR, PQIP delivery team, PQIP collaborative, PQIP delivery team and collaborative, PQIP Delivery Team, Ramani Moonesinghe S, Wagstaff D, Bedford J, Sahni A, McGuckin D, Gilhooly D, Santos C, Wilson J, Martin P, Singleton G, Edwards K, Vindrola-Padros C, Warnakulasuriya S, Dorey J, Leemans I, Martinez D, Lourtie J, Baumber R, Dorey J, Swift A, Jackson A, Belete M, Warwick E, Argent M, Brooks R, Fulop N, Brent A, Williams K, Grocott M, Mythen M, Olive D, Taylor C, Drake S, Swart M, Bougeard AM, Bedford M, Vallance A, Singh P, Vohra R, Ignacka A, Tucker O, Aresu G, Cripps M, Ellicott H, Samuel K, Chazapis M, Hunt AF, Lusby E, Durrand J, Weerasuriya S, PQIP Collaborative, Batchelor A, Snowden C, Murray D, Evans E, Vaux E, Abercrombie J, McGhie J, Dhesi J, Clark T, Crossley A, McGrath J, Digner M, Hamilton M, Hill R, Shinde S, Brett S.   +77 more
europepmc   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source