Results 151 to 160 of about 399,246 (222)

ROS-mediated membrane damage and antioxidant imbalance drive apple flesh browning during cold storage. [PDF]

Front Plant Sci
Wang J, Li F, Li B, Li L, Shang J, Fu X, Zhao X, Li X, Zhang X, Ahmed ZFR.   +9 more
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Effects of dietary supplementation with a thymol-carvacrol blend on growth performance and intestinal health of poultry. [PDF]

Front Vet Sci
Liu X, Li X, Chen R, Liu J, Liu R, Zhao R, Luo A, Zhao J, Hao J, Yang S, Chen A.   +10 more
europepmc   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Ginseng polysaccharides ameliorate DSS-induced inflammatory bowel disease by regulating gut microbiota in dogs. [PDF]

Front Vet Sci
Xie L, Li X, Mao A, Han Z, Zhang X, Liu X, Liu Q, Zhao W, Xu C.   +8 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

A cross-sectional study of salivary and gut microbiomes in hemodialysis patients with heart failure with preserved ejection fraction. [PDF]

Front Cell Infect Microbiol
Li L, Zhang Q, Zhang L, Wei R, Qin Y, Zhao J, Wu H.   +6 more
europepmc   +1 more source

Exclusive Se‐O Coordination and Fe‐doping Complementation: A Catalytic Strategy for Enhanced Sulfur Redox in Li‐S Batteries

Advanced Science, EarlyView.
Exclusive Se‐O coordination and Fe‐doping complementation significantly improve conductivity and modulate the d‐band centers, which strongly anchor polysulfides in bidirectional catalysis and reduce the energy barriers for the Li2S nucleation and dissociation, achieving high‐apacity retention, exceptional rate capability, and stable cycling capability.
Zhao Yang, Yu Wang, Jingchen Han, Tong Wu, Yongqing Fu, Qingsheng Wu, Ming Wen   +6 more
wiley   +1 more source

Single-cell transcriptomics reveals systemic immune dysregulation in non-segmental vitiligo. [PDF]

Front Immunol
Xiao J, Guo X, Gong L, Li Q, Dong K, Guo X, Li H, Wang T, Wang L, Wu W, Gan C, Li M, Gong B, Jiang Y, Wu Y, Hu Y, Han L, Yang J, Mao Y.   +18 more
europepmc   +1 more source