Results 161 to 170 of about 396,242 (246)

Vegetation C: N: P stoichiometry and ecosystem carbon storage under different grazing patterns on the Tibetan Plateau. [PDF]

Front Plant Sci
He G, Liu X, Li Y, Ji T.
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

NQO1/p65/CXCL12 Axis-Recruited Tregs Mediate Resistance to Anti-PD-1 Plus Lenvatinib Therapy in PIVKA-II-Positive Hepatocellular Carcinoma. [PDF]

Adv Sci (Weinh)
Gao B, Wang Y, Sun Z, Tang H, Cao Y, Jiang H, Zhang W, Xu Y, Hu B, Liu Z, Mao G, Li X, Li J, Wan T, Liu B, Zhao X, Jiao S, Li C, Lu S.   +18 more
europepmc   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Influence of antibiotic resistance on disinfectant tolerance of Escherichia coli, Staphylococcus aureus, Enterococcus faecium and Campylobacter jejuni. [PDF]

Access Microbiol
Davies E, Lindridge M, Gosling RJ, Smith RP, Oastler C.   +4 more
europepmc   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

The role of AI-enhanced fast delivery services in strengthening customer retention and loyalty in competitive markets. [PDF]

Front Artif Intell
Kasoju A, Vishwakarma T, Kasoju A.
europepmc   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Level of discharge readiness and influencing factors in ischaemic stroke patients: a descriptive, cross-sectional study. [PDF]

Front Neurol
Bai X, Gao L, Li H, Li R, Zhang Y, Han L, Liang D, Wang Y, Zhang Y, Yang W.   +9 more
europepmc   +1 more source

Predicting MammaPrint Recurrence Risk from Breast Cancer Pathological Images Using a Weakly Supervised Transformer

Advanced Science, EarlyView.
This study presents CPMP, a weakly supervised transformer model that predicts MammaPrint recurrence risk directly from routine histopathological images of early‐stage HR+/HER2− breast cancer patients. CPMP enables spatial heatmap visualization, analysis of cellular‐level interaction patterns, and an in‐depth characterization of morphological phenotypes
Chaoyang Yan, Linwei Li, Xiaolong Qian, Yang Ou, Zhidong Huang, Zhihan Ruan, Wenting Xiang, Hong Liu, Jian Liu   +8 more
wiley   +1 more source