Results 171 to 180 of about 396,242 (246)

Metabolomics combined with transcriptomics reveals the formation mechanism of different leaf colors of <i>Heuchera micrantha</i>. [PDF]

Front Plant Sci
Wang Y, Tang Y, Chen X, Yang X, Zhou Q, Hu Y, Meng X, Peng J.   +7 more
europepmc   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Advanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang, Lili Niu, Xiang Ding, Mengmeng Zhang, Zhensheng Xie, Tanxi Cai, Xiaojing Guo, Jianming Luo, Peng An, Xiangqian Guo, Fuquan Yang   +13 more
wiley   +1 more source

Manganese toxicity impairs soil nitrification and sugarcane nitrogen utilization by inhibiting rhizosphere ammonia-oxidizing microorganisms. [PDF]

Front Plant Sci
Zhu H, Pan J, Qin Y, Wei Y, Li X, Yang S, Chen B, Zhong T, Zhang T, Tang X.   +9 more
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

International variations in body mass index within the CASiRe global cohort of sickle cell disease patients. [PDF]

J Sick Cell Dis
Strunk C, Rivers A, Segbefia C, Colombatti R, Tartaglione I, Manwani D, Asare EV, Piccone CM, Boruchov D, Zempsky WT, Dankwah Boatemaa G, Mahesh Ramachandra Rao S, Akatue S, Oteng B, Owda A, Bamfo R, Wilson SR, Farooq F, Urbonya R, Barber J, Sey F, Inusa B, Antwi-Boasiako C, Andemariam B, Campbell AD.   +24 more
europepmc   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Revealing dietary habits and intestinal microbiome composition of the Beijing swift (<i>Apus apus pekinensis</i>) through regurgitated pellets and fecal samples. [PDF]

Front Microbiol
Wang B, Zhang Y, Li J, Wu M, Shi Y, Sun X, Xiao X, Zhang P, Shi Y, Li Y, Tian H.   +10 more
europepmc   +1 more source

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, EarlyView.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

Lily polysaccharides alleviate colitis through the microbiota-N8-acetylspermidine-cGAS-STING signaling axis. [PDF]

Front Microbiol
Wu Y, Wan X, Hou L, Zhang H, Wang J, Wu K, Shao J, Song Z.   +7 more
europepmc   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source