Results 21 to 30 of about 396,242 (246)
Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceMeasurement of the $$t\bar{t}$$ production cross-section and lepton differential distributions in $$e\mu $$ dilepton events from pp collisions at $$\sqrt{s}=13\,\text {TeV}$$ with the ATLAS detector
The European Physical Journal C, 2020 The inclusive top quark pair ($$t\bar{t}$$
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G. Aad, A. Kupco, S. Webb, T. Dreyer, Yufeng Wang, K. Jakobs, B. Le, M. Spousta, M. Cobal, Peilong Wang, S. Schmitt, J. Schovancová, A. Bassalat, M. Melo, M. Shapiro, G. Tarna, S. Zimmermann, T. Eifert, L. Rehnisch, S. Kuday, F. Legger, M. Sioli, H. Herr, N. Bruscino, F. Giorgi, J. Huston, T. Sumida, S. Robertson, R. Gonçalo, A. Snesarev, L. Rotonda, D. Duschinger, J. Thomas, E. Carquin, Y. W. Y. Ng, S. Crépé-Renaudin, J. Parsons, W. Balunas, Y. Tikhonov, Y. Tikhonov, M. K. Ayoub, J. A. Pozo, C. Mwewa, David Miller, A. Ivina, P. Mastrandrea, Jan-Ulf Mjoernmark, W. Leight, A. Colijn, Liaoshan Shi, M. E. Nelson, K. Cerny, N. Warrack, H. Krueger, J. Ocariz, M. Nordberg, C. Weber, Daniela Bortoletto, A. Lankford, N. Sinev, S. Tapprogge, Y. Hu, F. Parodi, T. Masubuchi, D. E. F. Lima, T. LeCompte, Shenjian Chen, S. Batlamous, T. Martin, J. Poveda, C. Roda, T. N. Manh, M. Ouchrif, K. Korcyl, T. Lyubushkina, C. Grefe, P. Tipton, F. Klitzner, A. Valero, T. Kishimoto, K. Kawagoe, H. Bachacou, A. Policicchio, F. Speiser, S. Zambito, S. Karpov, P. Strizenec, C. Lester, D. Casper, S. K. Haghighat, J. Navarro, Shuzhou Zhang, B. Micco, S. Koperny, L. Schaefer, C. Bertella, P. Schwemling, M. Vos, E. Meoni, T. Holmes, I. Sanderswood, Zhi Zheng, Z. Hubacek, C. Doglioni, A. Ferrante, L. Vigani, A. Nag, A. Boldyrev, S. R. Maschek, J. Stark, E. Yatsenko, P. Gessinger-Befurt, M. Kuze, B. Hooberman, S. Carrá, K. Pachal, D. Costanzo, M. Fenton, Jesse Liu, A. Klimentov, S. P. Griso, I. Panagoulias, T. Huffman, Hongbin Liu, T. Kuhl, G. Gustavino, M. Dyndał, F. An, M. Antonelli, B. Malaescu, D. K. Abhayasinghe, K. Grimm, D. Zanzi, Sundeep Singh, M. Eggleston, V. R. Bailey, A. Ezhilov, D. Yallup, A. Bellerive, J. Masik, A. Loesle, L. Adamek, L. Barak, D. Godin, G. Iacobucci, E. Shulga, B. Gorini, J. Heilman, D. Zhong, J. Butler, H. Fox, S. Grancagnolo, H. Cheng, C. Garner, S. Pino, N. Madysa, K. Black, G. Hallewell, L. Franconi, L. Horyn, D. Fassouliotis, J. Smith, A. Tricoli, M. Dumancic, H. Iwasaki, M. Kuna, M. Giannelli, B. Stapf, T. Cao, Michela Paganini, V. Ellajosyula, I. Pogrebnyak, E. Petit, E. Antipov, J. Faltova, Y. Chiu, Wenzhong Guo, S. Swift, E. Lipeles, A. Ducourthial, B. Bergmann, S. Artz, M. Oreglia, E. Drechsler, K. Einsweiler, F. Monticelli, S. Giagu, E. Kneringer, B. Freund, H. Yildiz, D. Whiteson, A. Dewhurst, K. Shaw, Yingchun Zhu, N. Biesuz, J. Terron, D. S. Nielsen, M. G. Bostanabad, S. P. Yuen, V. C. Gimenez, T. Barillari, T. Neep, F. Peri, P. Clark, S. Schier, K. Vorobev, J. Hrivnac, M. Barisits, T. Kunigo, A. Grillo, S. Camarda, T. Vale, R. Kopeliansky, M. Swiatlowski, N. Konstantinidis, O. Jinnouchi, H. Sadrozinski, V. Kazanin, V. Kazanin, E. Barberio, J. Pacalt, K. Tackmann, D. Pietreanu, R. Kass, Y. Kano, D. C. Munoz, J. Zahreddine, M. Sutton, Y. Noguchi, L. Živković, L. Dell’asta, V. Wallangen, K. Abeling, M. Vincter, G. Herten, V. Nikolaenko, D. Kirchmeier, C. Chau, A. Girolamo, N. Abraham, M. Elsing, C. Geng, K. Mochizuki, A. Ciaccio, B. Burghgrave, A. Fray, P. Massarotti, L. Rossini, S. Bahrasemani, C. J. Mcnicol, G. Gregorio, F. Corriveau, K. Tariq, G. Rodriguez, I. Bloch, K. Smolek, R. Brenner, P. Ott, P. Tas, A. Gomez, G. Marceca, B. Petersen, V. Solovyev, B. Haney, S. Gonzalez-Sevilla, C. Shimmin, P. Schacht, N. Whallon, A. Negri, S. Farrington, M. Ziolkowski, V. Cindro, P. Sommer, A. Minaenko, S. Honda, X. Ruan, P. F. Salvatore, M. Franklin, B. Mansoulie, Yang Qin, G. Galster, C. Leggett, J. Cowley, P. Buchholz, K. Zoch, Zuzana Blenessy, C. Ferretti, D. Biedermann, J. Kroll, E. M. Shrif, Z. Uysal, A. Behera, H. Torre, H. Torre, C. E. Leitgeb, F. Tresoldi, S. Che, S. Oda, C. Gutschow, M. Saito, F. L. Sterzo, D. Mungo, J. Vossebeld, J. Moss, M. Dunford, R. Middleton, A. Kowalewska, Kyungeon Choi, S. Harkusha, P. Saha, J. Hrdinka, R. Roehrig, H. Sakamoto, E. Hansen, Matt Zhang, A. Bailey, M. Biglietti, S. Jones, T. Jakoubek, L. Marcoccia, S. Connell, A. Doria, Hoang Dai Nghia Nguyen, M. Danninger, C. Blocker, S. Istin, E. Varnes, J. Hansen, M. Ghneimat, G. Iakovidis, A. Picazio, C. J. Treado, G. Jarlskog, K. Nagai, W. Vandelli, T. H. Park, A. Salvo, A. Kourkoumeli-Charalampidi, Y. Heng, F. Sohns, P. Shatalov, Y. Smirnov, S. Majewski, K. Sliwa, J. G. Rojas, P. Bechtle, M. Fiolhais, F. H. Phillips, F. Ito, F. Ukegawa, A. Alonso, T. Guillemin, E. Winkels, J. J. Kempster, A. Ghosh, Shuo Han, I. Maznas, M. Wobisch, K. Augsten, J. Ochoa, M. V. B. Pinto, E. Guirriec, N. Belyaev, A. Ryzhov, D. Moreno, G. Usai, P. Deviveiros, M. Shehade, M. Stanitzki, L. Wilkins, B. King, B. King, A. P. Pages, M. Begel, G. Forcolin, A. Mincer, Yongsung Kim, L. Morvaj, C. Burton, M. Weber, T. Heim, A. Rej, K. Belotskiy, A. Soukharev, A. Soukharev, J. Jeong, C. Agheorghiesei, H. Pacey, R. Carney, A. Chuinard, R. Jansky, A. Kotsokechagia, A. Undrus, B. Stamas, M. W. O'Keefe, J. M. I. Ponce, D. Boscherini, C. Zhu, D. Tovey, N. Semprini-Cesari, P. Fassnacht, K. Finelli, B. Brickwedde, A. Matic, C. David, L. Zwalinski, M. A. Verzini, R. Kukla, T. Stevenson, Jie Yu, D. Boerner, C. Galea, L. Heinrich, G. Rovelli, C. Troncon, F. Guescini, D. Denysiuk, J. Pascual, M. Kacimi, Chunhui Chen, A. Perez, S. Menke, I. Vulpen, E. Shabalina, G. Unal, R. Gardner, A. Fehr, Yu Zhang, N. Norjoharuddeen, M. Morii, A. Sciandra, T. Kosek, Zhiqin Zhang, K. Sekhon, R. Iguchi, Tai-hua Lin, L. Flores, G. Chiodini, A. Caltabiano, Jun-Jie Guo, Li Zhi, J. Gonski, A. Gabrielli, E. Akilli, T. Klapdor-Kleingrothaus, O. Kind, R. Schamberger, A. Schwartzman, L. A. Bella, F. Ruehr, A. Weidberg, A. Traeet, L. Mijović, H. Potti, S. Snyder, U. Blumenschein, R. Konoplich, P. Maettig, M. Javurkova, E. Celebi, E. Tzovara, M. Tasevsky, F. Pasquali, C. Solans, J. Kvita, S. Heim, V. Boisvert, B. Allen, T. Yamazaki, R. Hunter, S. Veneziano, M. Zaazoua, Y. Hasegawa, Y. Takubo, M. Huhtinen, A. Kiryunin, A. Beddall, N. Kimura, S. Amoroso, L. B. Navarro, L. Serkin, H. Pikhartova, Dengfeng Zhang, I. Gkialas, S. Smirnov, M. Haleem, D. Froidevaux, B. Ali, F. Lyu, D. Emeliyanov, A. Filipčič, S. Kuehn, M. Lassnig, T. Pauly, A. Redelbach, A. Struebig, I. Nitsche, B. Wosiek, Yang Liu, S. Strandberg +499 moresemanticscholar +1 more sourcePhenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer +9 morewiley +1 more sourceVisual analysis of document triage data [PDF]
, 2011 As part of the information seeking process, a large amount of effort is invested in order to study and understand how information seekers search through documents such that they can assess their relevance. This search and assessment of document relevance,Buchanan, George R., Laramee, Robert S., Loizides, Fernando, Zhao, Geng +3 morecore +1 more source
