Results 91 to 100 of about 2,604,224 (268)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Yleisten kirjastojen asiakkaat elektronisten aineistojen käyttäjinä

Informaatiotutkimus, 2010
Katsaus perustuu Kati Mattssonin informaatiotutkimuksen pro gradu -tutkielmaan; Elektronisten aineistojen käyttö yleisissä kirjastoissa. Mattssonin tutkimus on osa FinELibin ja Tampereen yliopiston Informaatiotutkimuksen laitoksen yhteistyötä, jonka ...
Kati Mattsson, Elina Late
doaj  

Recommendation: Forty years later: The status of the “Big Five” mass extinctions — R2/PR14

, 2022
Charles R. Marshall
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

QUESTIONAMENTOS FILOSÓFICOS SOBRE O INCONSCIENTE, ESBOÇO PARA UMA METAFISICA DO INCONSCIENTE

Reflexão
Não entendemos neste ensaio enfrentar o problema do inconsciente com as categorias da filosofia clássica, do racionalismo clássico ou do naturalismo materialista.
Luigino Valentini
doaj  

Association of inflammatory markers with clinical outcome in COVID-19 patients during the second wave in 100 bedded dedicated COVID MCH Hospital, Raigarh, Chhattisgarh State

Asian Journal of Medical Sciences
Background: A novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) was the causative agent of coronavirus disease 2019 (COVID-19) pandemic 2019.
Pankaj Madhukar Luka , Ved Prakash Gilley , Anmol Madhur Minz , Harish Kumar , Manoj Kumar Minj   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sea Bathing and the Process of Its Acceptance in the Late Nineteenth-Century Japan

, 1985
Chiaki T. Oguchi
openalex   +2 more sources