Results 171 to 180 of about 2,604,224 (268)

Variations in yield and gluten proteins in durum wheat varieties under late‐season foliar versus soil application of nitrogen fertilizer in a northern Mediterranean environment

, 2017
Giovanna Visioli, Urbana Bonas, Cristian Dal Cortivo, Gabriella Pasini, Nelson Marmiroli, Giuliano Mosca, Teofilo Vamerali   +6 more
openalex   +2 more sources

Precessional Cyclicity of Seawater Pb Isotopes in the Late Miocene Mediterranean [PDF]

, 2019
Sevasti Modestou, Marcus Gutjahr, Marlies van der Schee, R. M. Ellam, Rachel Flecker   +4 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Late distant recurrence prediction model in premenopausal women with ER-positive/HER 2-negative breast cancer: A multicenter retrospective study. [PDF]

Breast
Shin DS, Lee J, Kang E, Noh D, Cheun JH, Lee JH, Son Y, Bae SJ, Kwon S, Lee HB, Ryu JM, Ahn SG.   +11 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Impact of age and rurality on colorectal cancer outcomes in the United States. [PDF]

Cancer Causes Control
Grunert C, Tsai MH, Rogers CR, Howard S, Hogg-Graham R, Martin C, Conwell D, Toriola AT, Bhakta A, Moore JX.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Prognostic impact of radiotherapy timing in WHO grade 2 and 3 meningiomas utilizing an integrated molecular-morphologic classification. [PDF]

J Neurooncol
Delbridge C, Hou HX, Hielscher T, Wiestler B, Negwer C, Schenck L, Peeken J, Diehl C, Borm K, Krieg S, Aftahy KA, Leiss SM, Schmidt-Graf F, Mitsdörffer M, Yakushev I, Von Deimling A, Gempt J, Meyer B, Combs SE, Sahm F, Bernhardt D.   +20 more
europepmc   +1 more source

Radial variation of attenuation and star formation in the largest late-type disks observed with GALEX [PDF]

, 2007
S. Boissier, A. Gil de Paz
openalex