Results 111 to 120 of about 734,073 (209)

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Global Burden and Temporal Trends of Early‐Onset Tracheal, Bronchial, and Lung Cancer: An Analysis of GLOBOCAN 2022 and GBD 2023 Data

Advanced Science, EarlyView.
This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian, Weihao Zhang, Yao Lu, Bruce F. O'Hara, Jingjing Hu, Hanqi Feng, Jing Di, Lei Zhang, Xueying Yang   +8 more
wiley   +1 more source

Improving equity in respiratory disease outcomes in Africa using data-driven tools: National Institute of Health Care and Research's (NIHR) EQUI-RESP-AFRICA project. [PDF]

J Glob Health
Rudan I, Ozoh OO, Agbre-Yace ML, Bigogo G, Dangor Z, Saidu Y, Uneke C, Kourouma KR, Mohammed J, Budzi M, Achy A, Adelabu Y, Adon A, Ayanda T, Baillie V, Chukwu O, Enyi A, Ezeonu T, Kalla I, Kanma-Okafor O, Karimu I, Komo T, Muchiti W, Nweke N, Okafor E, Osita M, Ouma A, Sheikh S, Sonyuy MF, Alexandra van Blydenstein S, Yavo W, Campbell H, Osei-Yeboah R, Adeloye D.   +33 more
europepmc   +1 more source

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Schistosoma-Salmonella co-infection in Africa: Epidemiology, biological mechanisms, and antimicrobial resistance: A systematic review and meta analysis. [PDF]

PLoS One
Berhe B, Negash H, Abadi T, Belay G, Alemu M, Abere A, Legese H, Deres A.   +7 more
europepmc   +1 more source

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

Advanced Science, EarlyView.
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang, Fei Lu, Yuebo Su, Xuming Wang, Hua Zheng, Zhiyun Ouyang   +5 more
wiley   +1 more source

Dos figuras (2020), África Pitarch

África Pitarch (València, 1990) es licenciada en Arquitectura Superior, carrera en la que exprimió su vocación artística y creativa. Muy pronto empezó a colaborar con sus ilustraciones en diferentes proyectos independientes, agencias de publicidad y ...
Pitarch, África
core  

Understanding the landscape for driving antimicrobial stewardship implementation at scale in South Africa. [PDF]

JAC Antimicrob Resist
Van Den Bergh D, Charani E, Bonaconsa C, Brink A, Du Plessis N, Messina A, Miller M, Schellack N, Tootla H, Von Pressentin KB, Mendelson M.   +10 more
europepmc   +1 more source

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

Predicted spatial distribution of the primary Lassa virus reservoir, the multimammate mouse, in Africa. [PDF]

Front Public Health
Lateef AM, Cobos ME, Agbajelola VI, Raghavan RK.   +3 more
europepmc   +1 more source