Results 61 to 70 of about 2,851,390 (300)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

BRICs en África Subsahariana: Distintas estrategias, mismo interés

Revista Neiba, 2014
Los BRICs están llamados a jugar un rol cada vez más relevante en la escena internacional por la contundencia de sus indicadores económicos: en conjunto, ocupan el 22% de la superficie continental, constituyen el 27% del PBI mundial y reúnen el 41,6% de ...
Agustina Marchetti
doaj   +1 more source

Semelhanças e diferenças na escrita da história da África Centro-Ocidental no século XVII: os casos de Cadornega e Cavazzi

Cadernos de Pesquisa do CDHIS, 2011
Este artigo utiliza duas fontes clássicas sobre a história da África Centro-Ocidental durante o século XVII: a Descrição histórica dos três reinos do Congo, Matamba e Angola, de Giovanni Antonio Cavazzi, e a História geral das guerras angolanas, de Antonio de Oliveira de Cadornega.
openaire   +1 more source

HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities

Open AIDS Journal, 2016
Global trends in HIV infection demonstrate an overall increase in HIV prevalence and substantial declines in AIDS related deaths largely attributable to the survival benefits of antiretroviral treatment.
A. Kharsany, Q. Karim
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Imagens do Museu Real da África Central: um acervo de relíquias do Congado do Triangulo Mineiro e Alto Paranaíba no CDHIS

Cadernos de Pesquisa do CDHIS, 2010
O artigo é uma síntese da pesquisa de doutoramento da autora no Programa de Pós-Graduação em História da PUC do Rio de Janeiro. Trata-se de uma abordagem da História Social da Cultura que reconstrói diálogos entre a memória dos congadeiros de Uberlândia/ MG e a cultura material dos povos da atual República Democrática do Congo - RDC.
openaire   +1 more source

Música, movimiento y lenguaje interior en la adquisición de una nueva lengua [PDF]

, 2019
La adquisición de una lengua extranjera comienza desde las edades tempranas. Este es un periodo fundamental para el desarrollo de las diferentes inteligencias que conforman nuestro conocimiento, de entre ellas nos centraremos, principalmente, en la ...
Álvarez Domínguez, África
core  

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source