Results 131 to 140 of about 672,847 (238)
Advanced Intelligent Systems, EarlyView.FTGRN introduces an LLM‐enhanced framework for gene regulatory network inference through a two‐stage workflow. It combines a Transformer‐based model, pretrained on GPT‐4 derived gene embeddings and regulatory knowledge, with a fine‐tuning stage utilizing single‐cell RNA‐seq data.
Guangzheng Weng +7 more
wiley +1 more source
American Journal of Community Psychology, EarlyView.Abstract Although peer support is central to the social model approach emphasized in sober living houses (SLHs), no longitudinal studies have examined helping among SLH residents. This longitudinal study examined benefits of helping in three contexts among SLH residents. Data were from 205 participants entering 28 SLHs across 2021–2023. Interviews were
Sarah E. Zemore +4 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective The objective of this study was to compare the long‐term safety profiles of ocrelizumab and rituximab in persons with multiple sclerosis (MS). Methods Using retrospective data from the University of California (UC) Health System, we simulated a target clinical trial. The primary cohort from UC San Francisco (UCSF) and a validation cohort from
Gabriel Cerono +3 more
wiley +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
Planeación transfronteriza: ¿un caso de provocación sofisticada?
Estudios Fronterizos, 1985 Este documento se propone examinar críticamente los argumentos de Hansen a favor de un marco formal y legalmente comprometido, para la planeación transfronteriza y cooperación en la frontera de Estados Unidos y México.
John Friedmann, Rebeca Morales
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Annals of Neurology, EarlyView.Objective Dopaminergic imaging is a key biomarker for both the investigation of the biology of Parkinson's disease and related synucleinopathies and the evaluation of potential therapies in clinical trials. This work presents a harmonized approach for quantifying dopaminergic molecular imaging tracers, such as [123I]ioflupane (dopamine transporter scan
Zhen Fan +174 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt +82 more
wiley +1 more source
Angewandte Chemie, EarlyView.Diese Studie untersucht den Einfluss von Spuren diverser Elemente des p‐Blocks in der elektrochemischen reduktiven Aminierung, wobei sich für Pb mit Bi eine weniger toxische Alternative gezeigt hat. Die Verwendung von Bi als Additiv wurde weiter optimiert, indem der Einfluss der Additivkonzentration, der Reaktionstemperatur und des Kathodenmaterials ...
Justus Kümper +5 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.This study investigates the impact of various p‐block element impurities in the electrochemical reductive amination and reveals with Bi a less toxic alternative for Pb. The utilization of Bi as additive was further optimized by studying the impact of additive concentration, reaction temperature, and cathode material on amine yield, offering new ...
Justus Kümper +5 more
wiley +1 more source
Journal of Applied Polymer Science, EarlyView.DIW 3D printing of silicone materials can be optimized by controlling their gelling behavior or curing mechanism with carbon nanotubes. This precision control results in high‐performance elastomer materials and is a model study for characterization methods.
G. M. Fazley Elahee +5 more
wiley +1 more source