Results 31 to 40 of about 672,847 (238)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Universidad y Salud, 2018 Introducción: El intento suicida es un problema de salud pública, las cifras aumentan a pesar de los programas preventivos, es necesario conocer su comportamiento en la población pediátrica y en la región.
Freddy Israel Pantoja-Chamorro +3 more
doaj +1 more source
, 1997 Alumna del pintor expresionista americano Robert Motherwell, Suzi Gablik parece haber pasado los últimos veinte años tratando de rebatir los valores aprendidos en su época de estudiante.
Martínez, Chus
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Anuario Lope de Vega: Texto, Literatura, CulturaLas comedias hagiográficas representan un género privilegiado para observar el correlato entre el microcosmos y el macrocosmos, pues con frecuencia dramatizan una pugna que pronto supera el plano estrictamente humano para establecer correspondencias con
Gaston Gilabert
doaj +1 more source
Conocimiento actual sobre el síndrome de la arteria mesentérica superior
Anales de Radiología, México, 2022 El síndrome de la arteria mesentérica superior (SAMS) tiene una prevalencia del 0-1% al 35%. Su etiología está asociada a múltiples factores que involucren una disminución aguda del índice de masa corporal, con la consecuente pérdida de la almohadilla
Juan P. Reyes-González +4 more
doaj +1 more source
Model charged cylindrical nanopore in a colloidal dispersion: charge reversal, overcharging and double overcharging [PDF]
, 2017 Using the hypernetted-chain/mean spherical approximation (HNC/MSA) integral equations we study the electrical double layer inside and outside a model charged cylindrical vesicle (nanopore) immersed into a primitive model macroions solution, so that the ...
González-Tovar, E., Lozada-Cassou, M.
core +5 more sources
Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih +40 more
wiley +1 more source
Hispania SacraEste estudio interpreta que el conjunto de imágenes del retablo mayor de la iglesia parroquial de Sant Miquel de Castelltallat (Sant Mateu de Bages) predica el próximo triunfo de la Iglesia; mensaje dispuesto para ser proclamado a los cuatro vientos ...
Rodolfo Galdeano Carretero
doaj +1 more source